1346554-47-9
1346554-47-9 structure
- Name: SKI-2852
- Chemical Name: SKI-2852
- CAS Number: 1346554-47-9
- Molecular Formula: C27H34FN5O4S
- Molecular Weight: 543.658
- Create Date: 2020-01-20 17:57:56
- Modify Date: 2023-01-18 09:56:01
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A highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively; demonstrates no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity; significantly reduces blood glucose and HbA1c levels and improves the lipid profiles in ob/ob mice, synergistically enhances the HbA1c-lowering effect of metformin in vivo.
| Name | SKI-2852 |
|---|
| Description | A highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively; demonstrates no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity; significantly reduces blood glucose and HbA1c levels and improves the lipid profiles in ob/ob mice, synergistically enhances the HbA1c-lowering effect of metformin in vivo. |
|---|---|
| References | References 1. Ryu JH, et al. J Med Chem. 2016 Nov 23;59(22):10176-10189. View Related Products by Target 11β-HSD |
| Molecular Formula | C27H34FN5O4S |
|---|---|
| Molecular Weight | 543.658 |