DB0614

Modify Date: 2023-01-14 11:56:14

DB0614 structure	Common Name	DB0614
	CAS Number	2769753-47-9	Molecular Weight	822.95
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₁H₄₂N₈O₇S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DB0614

DB0614 (Example 21) is a bifunctional compound targeted protein degradation of kinases. DB0614 degrades AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity[1].

Name	DB0614

Description	DB0614 (Example 21) is a bifunctional compound targeted protein degradation of kinases. DB0614 degrades AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase Signaling Pathways >> Cell Cycle/DNA Damage >> Wee1 Signaling Pathways >> Neuronal Signaling >> CaMK Research Areas >> Others Signaling Pathways >> Apoptosis >> Ferroptosis Signaling Pathways >> Autophagy >> ULK Signaling Pathways >> Cell Cycle/DNA Damage >> LIM Kinase (LIMK) Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Immunology/Inflammation >> Salt-inducible Kinase (SIK)
Target	CDK6 CDK16/Cyclin Y ULK1 Aurora Kinase SIK2 LIMK2
References	[1]. Gray Nathanael S, et al. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742[P]. 2022-05-05.

Molecular Formula	C₄₁H₄₂N₈O₇S₂
Molecular Weight	822.95

Dichloromethane
CAS#:75-09-2

Polyacrylic acid
CAS#:9003-01-4

sodium carbonate
CAS#:497-19-8

Silicon dioxide
CAS#:7631-86-9

Triethanolamine
CAS#:102-71-6

Demeton
CAS#:126-75-0

Water
CAS#:7732-18-5

4-(4-Piperidinyl)morpholine dihydrochloride
CAS#:53617-35-9

Diclofenac sodium
CAS#:15307-79-6

Budesonide
CAS#:51372-29-3

DB0614

Use of DB0614

Names

DB0614 Biological Activity

Chemical & Physical Properties