2769753-47-9

2769753-47-9 structure

Name: DB0614
Chemical Name: DB0614
CAS Number: 2769753-47-9
Molecular Formula: C₄₁H₄₂N₈O₇S₂
Molecular Weight: 822.95
Catalog: Signaling Pathways Apoptosis Ferroptosis
Create Date: 2022-10-08 08:42:45
Modify Date: 2023-01-14 11:56:14
DB0614 (Example 21) is a bifunctional compound targeted protein degradation of kinases. DB0614 degrades AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity[1].

Name	DB0614

Description	DB0614 (Example 21) is a bifunctional compound targeted protein degradation of kinases. DB0614 degrades AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase Signaling Pathways >> Cell Cycle/DNA Damage >> Wee1 Signaling Pathways >> Neuronal Signaling >> CaMK Research Areas >> Others Signaling Pathways >> Apoptosis >> Ferroptosis Signaling Pathways >> Autophagy >> ULK Signaling Pathways >> Cell Cycle/DNA Damage >> LIM Kinase (LIMK) Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Immunology/Inflammation >> Salt-inducible Kinase (SIK)
Target	CDK6 CDK16/Cyclin Y ULK1 Aurora Kinase SIK2 LIMK2
References	[1]. Gray Nathanael S, et al. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742[P]. 2022-05-05.

Molecular Formula	C₄₁H₄₂N₈O₇S₂
Molecular Weight	822.95