DNA-PK-IN-5

Modify Date: 2024-01-05 08:02:33

DNA-PK-IN-5 Structure
DNA-PK-IN-5 structure
Common Name DNA-PK-IN-5
CAS Number 2719736-43-1 Molecular Weight 418.45
Density N/A Boiling Point N/A
Molecular Formula C21H22N8O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DNA-PK-IN-5


DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-5 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of drug resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021204111A1, compound 2)[1].

 Names

Name DNA-PK-IN-5

 DNA-PK-IN-5 Biological Activity

Description DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-5 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of drug resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021204111A1, compound 2)[1].
Related Catalog
References

[1]. Xinhai Chen, et al. Aminopyrimidine compounds and their derivatives as dna-pk inhibitors. Patent WO2021204111A1.

 Chemical & Physical Properties

Molecular Formula C21H22N8O2
Molecular Weight 418.45
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