MMP-9-IN-5
Modify Date: 2024-04-09 11:53:58
MMP-9-IN-5 structure
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Common Name | MMP-9-IN-5 | ||
|---|---|---|---|---|
| CAS Number | 2581824-80-6 | Molecular Weight | 577.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H20IN3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MMP-9-IN-5MMP-9-IN-5 is a MMP-9 inhibitor (IC50: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits AKT activity (IC50: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers[1]. |
| Name | MMP-9-IN-5 |
|---|
| Description | MMP-9-IN-5 is a MMP-9 inhibitor (IC50: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits AKT activity (IC50: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers[1]. |
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| Related Catalog | |
| Target |
MMP-9:4.49 nM (IC50) MMP-1:104 nM (IC50) MMP-2:266 nM (IC50) MMP-13:280 nM (IC50) AKT:1.34 nM (IC50) |
| In Vitro | MMP-9-IN-5 (compound 8, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells[1]. MMP-9-IN-5 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively[1]. MMP-9-IN-5 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively [1]. MMP-9-IN-5 (3.1 nM, 24 h) inhibits cell migration in HepG-2 cells[1]. Cell Viability Assay[1] Cell Line: Wi-38, MCF-7, NFS-60, HepG-2 cells Concentration: 0-1 μM approximately Incubation Time: 72 h Result: Showed cytotoxicity with IC50s: 35.1 nM (Wi-38), 6.9 nM (MCF-7), 5.5 nM (NFS-60), 3.1 nM (HepG-2). Cell Migration Assay [1] Cell Line: HepG-2 Concentration: 3.1 nM Incubation Time: 24 h Result: Inhibited cell migration by 59.35%. |
| References |
| Molecular Formula | C27H20IN3O4 |
|---|---|
| Molecular Weight | 577.37 |