HCV-IN-40

Modify Date: 2025-08-21 06:57:51

HCV-IN-40 Structure
HCV-IN-40 structure
Common Name HCV-IN-40
CAS Number 2087916-66-1 Molecular Weight 594.32
Density N/A Boiling Point N/A
Molecular Formula C21H26BrFN3O9P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HCV-IN-40


HCV-IN-40 (Compound 18c) is a potent, orally active hepatitis C virus (HCV) nucleoside inhibitor with EC50 values of 0.259, 0.434 and 0.069 μM against GT1a, GT1b and GT1b CES1 replicons[1].

 Names

Name HCV-IN-40

 HCV-IN-40 Biological Activity

Description HCV-IN-40 (Compound 18c) is a potent, orally active hepatitis C virus (HCV) nucleoside inhibitor with EC50 values of 0.259, 0.434 and 0.069 μM against GT1a, GT1b and GT1b CES1 replicons[1].
Related Catalog
Target

EC50: 0.069 μM (GT1b CES1), 0.259 μM (GT1a), 0.434 μM (GT1b)[1]

In Vivo HCV-IN-40 (Compound 18c) (1 mg/kg) provides very high nucleotide triphosphate (TP) in dog liver[1].
References

[1]. Chris Krueger A, et al. Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus. Bioorg Med Chem. 2020 Jan 1;28(1):115208.

 Chemical & Physical Properties

Molecular Formula C21H26BrFN3O9P
Molecular Weight 594.32
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