2087916-66-1

2087916-66-1 structure

2087916-66-1 structure

Name: HCV-IN-40
Chemical Name: HCV-IN-40
CAS Number: 2087916-66-1
Molecular Formula: C₂₁H₂₆BrFN₃O₉P
Molecular Weight: 594.32
Catalog: Signaling Pathways Anti-infection HCV
Create Date: 2022-07-11 14:16:42
Modify Date: 2024-01-08 10:13:13
HCV-IN-40 (Compound 18c) is a potent, orally active hepatitis C virus (HCV) nucleoside inhibitor with EC50 values of 0.259, 0.434 and 0.069 μM against GT1a, GT1b and GT1b CES1 replicons[1].

Name	HCV-IN-40

Description	HCV-IN-40 (Compound 18c) is a potent, orally active hepatitis C virus (HCV) nucleoside inhibitor with EC50 values of 0.259, 0.434 and 0.069 μM against GT1a, GT1b and GT1b CES1 replicons[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection
Target	EC50: 0.069 μM (GT1b CES1), 0.259 μM (GT1a), 0.434 μM (GT1b)[1]
In Vivo	HCV-IN-40 (Compound 18c) (1 mg/kg) provides very high nucleotide triphosphate (TP) in dog liver[1].
References	[1]. Chris Krueger A, et al. Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus. Bioorg Med Chem. 2020 Jan 1;28(1):115208.

Molecular Formula	C₂₁H₂₆BrFN₃O₉P
Molecular Weight	594.32