HCV-IN-30

Modify Date: 2025-08-25 16:36:47

Use of HCV-IN-30

HCV-IN-30 (compound 48) is a HCV NS5A replication complex inhibitor, with IC50s of 901 and 102 nM for genotypes 1a and 1b replicons, respectively[1].

Name	di-tert-butyl (2S,2'S)-2,2'-(4,4'-biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-pyrrolidinecarboxylate)
Synonym	More Synonyms

Description	HCV-IN-30 (compound 48) is a HCV NS5A replication complex inhibitor, with IC50s of 901 and 102 nM for genotypes 1a and 1b replicons, respectively[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection
References	[1]. Belema M, et al. Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons. J Med Chem. 2014 Mar 13;57(5):1995-2012.

Bis(1,1-dimethylethyl) (2,2'-[[1,1'-biphenyl]-4,4'-diylbis(1H-imidazole-5,2-diyl)]bis(1-pyrrolidinecarboxylate)

Daclatasvir intermediate

Di-tert-butyl (2S,2'S)-2,2'-(4,4'-biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-pyrrolidinecarboxylate)

di-tert-butyl(2S,2'S)-2,2'-(4,4'-biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-pyrrolidinecarboxylate)

T5NTJ AVOX1&1&1 B- BT5M CNJ ER DR D- ET5M CNJ B- BT5NTJ AVOX1&1&1 &&(2S,2S'- Form

Bis(2-methyl-2-propanyl) (2S,2'S)-2,2'-[4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl)]di(1-pyrrolidinecarboxylate)

1-Pyrrolidinecarboxylic acid, 2,2'-[[1,1'-biphenyl]-4,4'-diylbis(1H-imidazole-5,2-diyl)]bis-, bis(1,1-dimethylethyl) ester, (2S,2'S)-

di-tert-butyl (2S,2'S)-2,2'-(4,4'-biphenyldiylbis(lH-imidazole-5,2-diyl))di(1-pyrrolidinecarboxylate)

(2S,2'S)-DI-TERT-BUTYL-2,2'-(4,4'-([1,1'-BIPHENYL]-4,4'-DIYL - )BIS(1H-IMIDAZOLE-4,2-DIYL))BIS(PYRROLIDINE-1-CARBOXYLATE)

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