HCV-IN-30

Names

[ Name ]:
HCV-IN-30

[Synonym ]:
Bis(1,1-dimethylethyl) (2,2'-[[1,1'-biphenyl]-4,4'-diylbis(1H-imidazole-5,2-diyl)]bis(1-pyrrolidinecarboxylate)
Daclatasvir intermediate
Di-tert-butyl (2S,2'S)-2,2'-(4,4'-biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-pyrrolidinecarboxylate)
di-tert-butyl(2S,2'S)-2,2'-(4,4'-biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-pyrrolidinecarboxylate)
T5NTJ AVOX1&1&1 B- BT5M CNJ ER DR D- ET5M CNJ B- BT5NTJ AVOX1&1&1 &&(2S,2S'- Form
Bis(2-methyl-2-propanyl) (2S,2'S)-2,2'-[4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl)]di(1-pyrrolidinecarboxylate)
1-Pyrrolidinecarboxylic acid, 2,2'-[[1,1'-biphenyl]-4,4'-diylbis(1H-imidazole-5,2-diyl)]bis-, bis(1,1-dimethylethyl) ester, (2S,2'S)-
di-tert-butyl (2S,2'S)-2,2'-(4,4'-biphenyldiylbis(lH-imidazole-5,2-diyl))di(1-pyrrolidinecarboxylate)
(2S,2'S)-DI-TERT-BUTYL-2,2'-(4,4'-([1,1'-BIPHENYL]-4,4'-DIYL - )BIS(1H-IMIDAZOLE-4,2-DIYL))BIS(PYRROLIDINE-1-CARBOXYLATE)

Biological Activity

[Description]:

HCV-IN-30 (compound 48) is a HCV NS5A replication complex inhibitor, with IC50s of 901 and 102 nM for genotypes 1a and 1b replicons, respectively[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV

Research Areas >> Infection

[References]

[1]. Belema M, et al. Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons. J Med Chem. 2014 Mar 13;57(5):1995-2012.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
890.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₆H₄₄N₆O₄

[ Molecular Weight ]:
624.772

[ Flash Point ]:
492.2±34.3 °C

[ Exact Mass ]:
624.342407

[ PSA ]:
116.44000

[ LogP ]:
5.69

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.600

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.