Pioglitazone-d4 (alkyl)

Modify Date: 2024-01-16 11:24:08

Pioglitazone-d4 (alkyl) structure	Common Name	Pioglitazone-d4 (alkyl)
	CAS Number	1134163-31-7	Molecular Weight	360.46300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₆D₄N₂O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Pioglitazone-d4 (alkyl)

Pioglitazone-d4 (alkyl) (U 72107-d4 (alkyl)) is the deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively[1][2].

Name	5-[[4-[1,1,2,2-tetradeuterio-2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Synonym	More Synonyms

Description	Pioglitazone-d4 (alkyl) (U 72107-d4 (alkyl)) is the deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Ferroptosis Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Kuwabara K, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose leve [3]. Puddu A, et al. Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15. Regul Pept. 2012 Aug 20;177(1-3):79-84. [4]. Kubota N, et al. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem. 2006 Mar 31;281(13):8748-55. [5]. Elrashidy RA, et al. Pioglitazone attenuates cardiac fibrosis and hypertrophy in a rat model of diabetic nephropathy. J Cardiovasc Pharmacol Ther. 2012 Sep;17(3):324-33.

Molecular Formula	C₁₉H₁₆D₄N₂O₃S
Molecular Weight	360.46300
Exact Mass	360.14500
PSA	97.08000
LogP	3.43550

Pioglitazone-Labeled d4

Pioglitazone-d4

AD-4833-d4

Actos-d4

Pioglitazone-d4 (alkyl)

Use of Pioglitazone-d4 (alkyl)

Names

Pioglitazone-d4 (alkyl) Biological Activity

Chemical & Physical Properties

Synonyms