L-penicillamine
L-penicillamine structure
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Common Name | L-penicillamine | ||
|---|---|---|---|---|
| CAS Number | 1113-41-3 | Molecular Weight | 149.211 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 251.8±35.0 °C at 760 mmHg | |
| Molecular Formula | C5H11NO2S | Melting Point | 206ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 106.1±25.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of L-penicillamineL-Penicillamine is a medication primarily used for the treatment of Wilson's disease. It is also used for people with kidney stones who have high urine cystine levels, rheumatoid arthritis, copper poisoning, and lead poisoning. It is taken by mouth. Common side effects include rash, loss of appetite, nausea, diarrhea, and low blood white blood cell levels. Other serious side effects include liver problems, obliterative bronchiolitis, and myasthenia gravis. It is not recommended in people with lupus erythematosus. Use during pregnancy may result in harm to the baby. Penicillamine works by binding heavy metals such that they can be removed from the body in the urine. |
Summary: L-penicillamine, Chinese name L-青霉胺, CAS number 1113-41-3, with molecular formula C5H11NO2S and molecular weight 149.211, is a white to off-white crystalline powder. It is primarily used for treating Wilson's disease, high cystine in urine, rheumatoid arthritis, copper poisoning, and lead poisoning. Common side effects include rash, loss of appetite, nausea, diarrhea, and low white blood cell levels. More severe side effects may include liver problems, obliterative bronchiolitis, and myasthenia gravis. Penicillamine is not recommended for individuals with lupus erythematosus. Use during pregnancy may harm the baby. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | L-penicillamine |
|---|---|
| Synonym | More Synonyms |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 251.8±35.0 °C at 760 mmHg |
| Melting Point | 206ºC (dec.) |
| Molecular Formula | C5H11NO2S |
| Molecular Weight | 149.211 |
| Flash Point | 106.1±25.9 °C |
| Exact Mass | 149.051056 |
| PSA | 102.12000 |
| LogP | 0.93 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.528 |
| InChIKey | VVNCNSJFMMFHPL-GSVOUGTGSA-N |
| SMILES | CC(C)(S)C(N)C(=O)O |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | YV9445500 |
| HS Code | 2930909090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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L-penicillamine CAS#:1113-41-3 |
| Literature: Journal of Biological Chemistry, , vol. 184, p. 63,68 |
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L-penicillamine CAS#:1113-41-3 |
| Literature: Journal of Biological Chemistry, , vol. 184, p. 63,68 |
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L-penicillamine CAS#:1113-41-3 |
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Literature: Chem.Penicillin, |
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L-penicillamine CAS#:1113-41-3 |
| Literature: US2543358 , ; |
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L-penicillamine CAS#:1113-41-3
Learn More
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| Literature: Journal of the Chemical Society, Faraday Transactions, , vol. 91, # 13 p. 1923 - 1930 |
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L-penicillamine CAS#:1113-41-3 |
| Literature: Journal of the Chemical Society, Faraday Transactions, , vol. 91, # 13 p. 1923 - 1930 |
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~%
L-penicillamine CAS#:1113-41-3
Learn More
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| Literature: Journal of the Chemical Society, Faraday Transactions, , vol. 91, # 13 p. 1923 - 1930 |
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~%
L-penicillamine CAS#:1113-41-3
Learn More
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| Literature: Journal of the Chemical Society, Faraday Transactions, , vol. 91, # 13 p. 1923 - 1930 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 7 | |
|---|---|
| DownStream 10 | |
CAS#:52-66-4
CAS#:186538-00-1
CAS#:640-68-6
CAS#:109-99-9
CAS#:72778-00-8
CAS#:117918-23-7
CAS#:110763-40-1
CAS#:123-91-1This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Circular muscle contraction in the mice rectum plays a key role in morphine-induced constipation.
Neurogastroenterol. Motil. 26(10) , 1396-407, (2014) Although opioids induce intestinal muscle contraction and provoke constipation, the intestinal region(s) that contribute to the constipation have remained unclear. We report here a region-specific res... |
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Inhibitors of bacterialN-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity
Bioorg. Med. Chem. Lett. 19 , 6350-2, (2009) A screen biased toward compounds containing zinc-binding groups (ZBG’s) delivered a number of micromolar inhibitors of DapE from Haemophilus influenzae, including l-captopril (IC 50 = 3.3 μM, K i = 1.... |
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Acetyl- and butyryl-cholinesterase inhibitory activities of the edible brown alga Eisenia bicyclis.
Arch. Pharm. Res. 38 , 1477-87, (2015) As part of our ongoing isolation of cholinesterase (ChE) inhibitors from natural marine sources, the bioactivity of the ethanolic extracts from 12 Korean seaweeds were screened for their inhibitory ac... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100
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Name: qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar...
Source: NCGC
Target: 67.9K protein [Vaccinia virus]
External Id: Vaccinia-p2mCherry
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Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101
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Name: Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
Source: NCGC
Target: N/A
External Id: TRND-SARS-CoV-2-cytotox-48hr
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Name: qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary ...
Source: NCGC
Target: 67.9K protein [Vaccinia virus]
External Id: Vaccinia-p2Venus
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Name: Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
Source: NCGC
External Id: TRND-SARS-CoV-2-PP
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Name: Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV)
Source: NCGC
External Id: APP-Toga-CHIKV-nsp2-p
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Name: Inhibition of Haemophilus influenzae recombinant DapE
Source: ChEMBL
Target: Succinyl-diaminopimelate desuccinylase
External Id: CHEMBL1101552
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Name: Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase...
Source: NCGC
External Id: GPx1-biochemical-p4-p7
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Name: qHTS for Inhibitors of binding or entry into cells for Marburg Virus
Source: NCGC
Target: gene 4 small orf - Marburg virus
External Id: VSVM-OFFLINE
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| EINECS 214-203-9 |
| L(+)-Penicillamine |
| 2-Amino-3-mercapto-3-methylbutanoic acid |
| 3-mercapto-L-valine |
| 3-Sulfanyl-L-valine |
| L-β,β-Dimethylcysteine |
| L-Penicillamine |
| (R)-penicillamine |
| (±)-penicillamine |
| DL-Penicillamine |
| β, β-Dimethyl-DL-cysteine |
| β,β-Dimethyl-DL-cysteine |
| L-β-Mercaptovaline |
| (2R)-2-amino-3-mercapto-3-methyl-butyric acid |
| (2R)-2-amino-3-mercapto-3-methylbutanoic acid |
| 3,3-Dimethyl-DL-cysteine |
| 3-Sulfanylvaline |
| MFCD00064303 |
| α-AMINO-β-METHYL-β-MERCAPTOBUTYRIC ACID |
| H-Pen-OH |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the LogP of L-penicillamine? |
| A: LogP of L-penicillamine is 0.93. |
| Q: What is the polar surface area (PSA) of L-penicillamine? |
| A: Polar surface area (PSA) of L-penicillamine is 102.12000. |
| Q: What is the boiling point of L-penicillamine? |
| A: Boiling point of L-penicillamine is 251.8±35.0 °C at 760 mmHg. |
| Q: What is the SMILES notation of L-penicillamine? |
| A: SMILES notation of L-penicillamine is CC(C)(S)C(N)C(=O)O. |
| Q: What are the downstream products of L-penicillamine? |
| A: Related downstream products(CAS) of L-penicillamine: 52-66-4;186538-00-1;640-68-6;107-21-1;58167-41-2;109-99-9;72778-00-8;117918-23-7;110763-40-1;123-91-1. |
| Q: What is the English name of L-penicillamine? |
| A: The English name of L-penicillamine is L-penicillamine. |
| Q: What is the melting point of L-penicillamine? |
| A: Melting point of L-penicillamine is 206ºC (dec.). |
| Q: What is the InChIKey of L-penicillamine? |
| A: InChIKey of L-penicillamine is VVNCNSJFMMFHPL-GSVOUGTGSA-N. |
| Q: What is the molecular formula of L-penicillamine? |
| A: Molecular formula of L-penicillamine is C5H11NO2S. |
| Q: What are the upstream materials of L-penicillamine? |
| A: Related upstream materials(CAS) of L-penicillamine: 2510-38-5;54536-38-8;71-23-8;58167-41-2;64-17-5;107-21-1;67-63-0. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |