thf

Modify Date: 2024-01-02 10:24:21

thf Structure
thf structure
 Common Name thf
CAS Number 109-99-9 Molecular Weight 72.106
Density 0.9±0.1 g/cm3 Boiling Point 66 ºC
Molecular Formula C4H8O Melting Point -108.4 ºC
MSDS Chinese USA Flash Point -21 ºC
Symbol GHS02 GHS07 GHS08
GHS02, GHS07, GHS08		 Signal Word Danger

 Names

Name Tetrahydrofuran
Synonym More Synonyms

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 66 ºC
Melting Point -108.4 ºC
Molecular Formula C4H8O
Molecular Weight 72.106
Flash Point -21 ºC
Exact Mass 72.057518
PSA 9.23000
LogP 0.33
Vapour density 2.5 (vs air)
Vapour Pressure 152.4±0.1 mmHg at 25°C
Index of Refraction 1.417
Water Solubility miscible
Freezing Point -108℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LU5950000
CHEMICAL NAME :
Furan, tetrahydro-
CAS REGISTRY NUMBER :
109-99-9
LAST UPDATED :
199712
DATA ITEMS CITED :
51
MOLECULAR FORMULA :
C4-H8-O
MOLECULAR WEIGHT :
72.12
WISWESSER LINE NOTATION :
T5OTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
25000 ppm
TOXIC EFFECTS :
Behavioral - general anesthetic
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GAFCC* GAF Material Safety Data Sheet. (GAF Chemicals Corporation, 1361 Alps Road, Wayne, NJ 07470)
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
21000 ppm/3H
TOXIC EFFECTS :
Behavioral - sleep Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
24000 mg/m3/2H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Liver - fatty liver degeneration
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4550 mg/kg/17W-I
TOXIC EFFECTS :
Blood - change in clotting factors Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1000 ppm/4H/12W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - deviated nasal septum
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5000 ppm/6H/91D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Endocrine - changes in thymus weight Blood - changes in erythrocyte (RBC) count
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 ppm/6H/18W-I
TOXIC EFFECTS :
Liver - other changes Musculoskeletal - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4550 mg/kg/17W-I
TOXIC EFFECTS :
Blood - change in clotting factors Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5000 ppm/6H/91D-I
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - adrenal cortex hypoplasia Endocrine - changes in thymus weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 gm/m3/2H/60D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
5000 ppm/6H
SEX/DURATION :
female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
1800 ppm/6H
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Escherichia coli
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 26(1),43,1982 *** REVIEWS *** ACGIH TLV-STEL 737 mg/m3 (250 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 590 mg/m3 (200 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 200 ppm (590 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,252,1971 OSHA PEL (Gen Indu):8H TWA 200 ppm (590 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 200 ppm (590 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 200 ppm (590 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 200 ppm (590 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 200 ppm (590 mg/m3);STEL 250 ppm (735 mg/m3) JAN 1993 OEL-BELGIUM:TWA 200 ppm (590 mg/m3);STEL 250 ppm (738 mg/m3) JAN 1993 OEL-DENMARK:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-FINLAND:TWA 100 ppm (290 mg/m3);STEL 150 ppm (440 mg/m3) JAN 1993 OEL-FRANCE:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-GERMANY:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-HUNGARY:TWA 200 mg/m3;STEL 400 mg/m3 JAN 1993 OEL-JAPAN:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-RUSSIA:TWA 200 ppm;STEL 100 mg/m3 JAN 1993 OEL-SWEDEN:TWA 100 ppm (300 mg/m3);STEL 150 ppm (450 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 200 ppm (590 mg/m3);STEL 1000 ppm JAN 1993 OEL-TURKEY:TWA 200 ppm (590 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 200 ppm (590 mg/m3);STEL 250 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TETRAHYDROFURAN-air:10H TWA 200 ppm;STEL 250 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 71695 No. of Facilities: 4141 (estimated) No. of Industries: 72 No. of Occupations: 60 No. of Employees: 95003 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 71695 No. of Facilities: 17866 (estimated) No. of Industries: 101 No. of Occupations: 83 No. of Employees: 356038 (estimated) No. of Female Employees: 47382 (estimated)

 Safety Information

Symbol GHS02 GHS07 GHS08
GHS02, GHS07, GHS08
Signal Word Danger
Hazard Statements H225-H302-H319-H335-H351
Supplemental HS May form explosive peroxides.
Precautionary Statements P210-P280-P301 + P312 + P330-P305 + P351 + P338-P370 + P378-P403 + P235
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes F:Flammable
Risk Phrases R11;R19;R36/37
Safety Phrases S26-S36-S33-S29-S16
RIDADR UN 2924 3/PG 2
WGK Germany 1
RTECS MD0916000
Packaging Group II
Hazard Class 3
HS Code 2932110000

 Synthetic Route

 Customs

HS Code 2932110000
Summary 2932110000 tetrahydrofuran。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.0%。general tariff:20.0%

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 Synonyms

tetrahydro-furan
THF
oxolane
EINECS 203-786-5
MFCD00148879
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Related Compounds: More...
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Chemsrc provides thf(CAS#:109-99-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of thf are included as well.>> amp version: thf

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