D-erythro-Sphingosine
D-erythro-Sphingosine structure
|
Common Name | D-erythro-Sphingosine | ||
|---|---|---|---|---|
| CAS Number | 123-78-4 | Molecular Weight | 299.492 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 445.9±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H37NO2 | Melting Point | 81-82ºC | |
| MSDS | Chinese USA | Flash Point | 223.5±28.7 °C | |
Use of D-erythro-SphingosineD-erythro-Sphingosine is a very potent activator of p32-kinase with an EC50 of 8 μM. D-erythro-Sphingosine inhibits protein kinase C (PKC). |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | sphingosine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | D-erythro-Sphingosine is a very potent activator of p32-kinase with an EC50 of 8 μM. D-erythro-Sphingosine inhibits protein kinase C (PKC). |
|---|---|
| Related Catalog | |
| Target |
p32:8 μM (EC50) PKC Human Endogenous Metabolite |
| In Vitro | A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines[1]. D-erythro-Sphingosine inhibits protein kinase C in vitro[2]. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells[3]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 0.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 445.9±45.0 °C at 760 mmHg |
| Melting Point | 81-82ºC |
| Molecular Formula | C18H37NO2 |
| Molecular Weight | 299.492 |
| Flash Point | 223.5±28.7 °C |
| Exact Mass | 299.282440 |
| PSA | 66.48000 |
| LogP | 6.40 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.489 |
| Water Solubility | chloroform: 20 mg/mL |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2922199090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 7 | |
|---|---|
| DownStream 10 | |
CAS#:116467-63-1![2-phenyl-4-(S)-[(1R,2E)-1-(trimethylsilanyl-oxy)hexadec-2-enyl]-1,3-oxazoline Structure](https://image.chemsrc.com/caspic/306/572922-39-5.png)
CAS#:572922-39-5
CAS#:105308-75-6
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CAS#:115464-03-4
CAS#:1094213-80-5
CAS#:511542-07-7
CAS#:10575-28-7
CAS#:3102-57-6
CAS#:26993-30-6
CAS#:544-63-8
CAS#:638-53-9
CAS#:54164-50-0
CAS#:764-22-7
CAS#:74713-60-3
CAS#:74713-59-0This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2922199090 |
|---|---|
| Summary | 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Sphingosine kinase 1 contributes to leptin-induced STAT3 phosphorylation through IL-6/gp130 transactivation in oestrogen receptor-negative breast cancer.
Breast Cancer Res. Treat. 149(1) , 59-67, (2015) Obesity is a known risk factor for breast cancer. We have recently identified that adipokine leptin regulates the expression of a proto-oncogenic enzyme sphingosine kinase 1 (SK1). Signal transducer a... |
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Sphingosine kinase 1 isoform-specific interactions in breast cancer.
Mol. Endocrinol. 28(11) , 1899-915, (2014) Sphingosine kinase 1 (SK1) is a signaling enzyme that catalyzes the formation of sphingosine-1-phosphate. Overexpression of SK1 is causally associated with breast cancer progression and resistance to ... |
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Fungal metabolite myriocin promotes human herpes simplex virus-2 infection.
Life Sci. 120 , 31-8, (2015) Myriocin is a fungal metabolite with antiviral activity, including influenza, hepatitis B, and hepatitis C viruses. We investigated whether myriocin has activity against human HSV-2, one of the most p... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| EINECS 204-651-3 |
| (4E)-sphing-4-enine |
| D-erythro-Sphingosine,synthetical |
| BRAIN,BOVINE |
| MFCD00036751 |
| Sphingosine, D-erythro |
| DErySphingosine |
| [3H]-Sphingosine |
| 4-trans-Sphingenine |
| Sphingosine |
| 4-Sphingenine |
| [Fluorescein]-Sphingosine |
| (2S,3R,4E)-2-Aminooctadec-4-ene-1,3-diol |
| Sphingenine |
| EGG SPHINGOSINE |
| D-erythro-Sphingosine |
| D-Sphingosine |
| erythro-4-Sphingenine |
| CEREBROSIDE |
| (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol |
| (-)-D-erythro-Sphingosine |
| (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-ene-1-ol |
| BRAIN SPHINGOSINE |
| (4E)-sphingenine |
| trans-4-sphingenine |
| D-erythrosphingosine |
| C18-Sphingosine |
| (2S,3R,E)-2-Amino-4-octadecene-1,3-diol |
| Sphingosine 2S,3R,2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol |
| UNII:0Y6SVQ612Q |
| (4E)-2-Aminooctadec-4-ene-1,3-diol |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the melting point of sphingosine? |
| A: Melting point of sphingosine is 81-82ºC. |
| Q: What are the uses of sphingosine? |
| A: Main uses of sphingosine: D-erythro-Sphingosine is a very potent activator of p32-kinase with an EC50 of 8 μM. D-erythro-Sphingosine inhibits protein kinase C (PKC). |
| Q: What is the CAS number of sphingosine? |
| A: CAS number of sphingosine is 123-78-4. |
| Q: How is the water solubility of sphingosine? |
| A: Water solubility of sphingosine: chloroform: 20 mg/mL. |
| Q: What are the upstream materials of sphingosine? |
| A: Related upstream materials(CAS) of sphingosine: 116467-63-1;572922-39-5;105308-75-6;103348-49-8;115464-03-4;1094213-80-5;511542-07-7. |
| Q: What are the downstream products of sphingosine? |
| A: Related downstream products(CAS) of sphingosine: 10575-28-7;3102-57-6;123-78-4;26993-30-6;544-63-8;638-53-9;54164-50-0;764-22-7;74713-60-3;74713-59-0. |
| Q: What is the polar surface area (PSA) of sphingosine? |
| A: Polar surface area (PSA) of sphingosine is 66.48000. |
| Q: What is the molecular formula of sphingosine? |
| A: Molecular formula of sphingosine is C18H37NO2. |
| Q: What is the English name of sphingosine? |
| A: The English name of sphingosine is sphingosine. |
| Q: What is the safety information for sphingosine? |
| A: Safety information for sphingosine: 22-24/25. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |