Nedaplatin
Nedaplatin structure
|
Common Name | Nedaplatin | ||
|---|---|---|---|---|
| CAS Number | 95734-82-0 | Molecular Weight | 303.181 | |
| Density | N/A | Boiling Point | 265.6ºC at 760 mmHg | |
| Molecular Formula | C2H8N2O3Pt | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 128.7ºC | |
Use of NedaplatinNedaplatin is a derivative of cisplatin and DNA damage agent.Target: OthersNedaplatin(NDP) is a derivative of cisplatin which produced less nausea & vomiting and nephrotoxicity. the effect of NDP on the 7-ethyl-1-hydroxy-CPT (the active form of CPT-11)-induced inhibitory effect on DNA topoisomerase I was examined. The topoisomerase I-inhibitory effect of 7-ethyl-1-hydroxy-CPT was enhanced 10-fold in the presence of NDP at microgram/milliliter concentrations [1]. NDP was developed as a second generation platinum complex. Because it has greater antitumour activity and lower nephrotoxicity than cisplatin (CDDP). At the high-dose of NDP in FN therapy, a reduction of tumour size and long-term tumour-free survival were frequently observed. The survival effect of the combinations of NDP with 5-FU was superior to those of the combination of CDDP with 5-FU. In conclusion, the sequence-dependent antitumour efficacy and toxicity of the combination of NDP or CDDP with 5-FU was demonstrated in this study, and FN therapy appeared to be the most efficient regimen as a clinical therapy [2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | nedaplatin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Nedaplatin is a derivative of cisplatin and DNA damage agent.Target: OthersNedaplatin(NDP) is a derivative of cisplatin which produced less nausea & vomiting and nephrotoxicity. the effect of NDP on the 7-ethyl-1-hydroxy-CPT (the active form of CPT-11)-induced inhibitory effect on DNA topoisomerase I was examined. The topoisomerase I-inhibitory effect of 7-ethyl-1-hydroxy-CPT was enhanced 10-fold in the presence of NDP at microgram/milliliter concentrations [1]. NDP was developed as a second generation platinum complex. Because it has greater antitumour activity and lower nephrotoxicity than cisplatin (CDDP). At the high-dose of NDP in FN therapy, a reduction of tumour size and long-term tumour-free survival were frequently observed. The survival effect of the combinations of NDP with 5-FU was superior to those of the combination of CDDP with 5-FU. In conclusion, the sequence-dependent antitumour efficacy and toxicity of the combination of NDP or CDDP with 5-FU was demonstrated in this study, and FN therapy appeared to be the most efficient regimen as a clinical therapy [2]. |
|---|---|
| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 265.6ºC at 760 mmHg |
|---|---|
| Molecular Formula | C2H8N2O3Pt |
| Molecular Weight | 303.181 |
| Flash Point | 128.7ºC |
| Exact Mass | 303.018280 |
| PSA | 42.01000 |
| LogP | 0.12010 |
| InChIKey | KLNFSAOEKUDMFA-UHFFFAOYSA-M |
| SMILES | O=C([O-])CO.[NH2-].[NH2-].[Pt+2] |
| Storage condition | 2-8°C |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xn |
|---|
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
|
~28%
Nedaplatin CAS#:95734-82-0 |
| Literature: Totani, Tetsushi; Aono, Katsutoshi; Komura, Michihiro; Adachi, Yasuko Chemistry Letters, 1986 , p. 429 - 432 |
|
~43%
Nedaplatin CAS#:95734-82-0 |
| Literature: Totani, Tetsushi; Aono, Katsutoshi; Komura, Michihiro; Adachi, Yasuko Chemistry Letters, 1986 , p. 429 - 432 |
|
~%
Nedaplatin CAS#:95734-82-0 |
| Literature: Chemistry Letters, , p. 429 - 432 |
2} structure](https://image.chemsrc.com/caspic/323/63700-88-9.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 4 | |
|---|---|
| DownStream 0 | |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (glycolato-O,O')diammine platinum(II) |
| 2,2-diaMino-1,3-dioxa-2-platinacyclopentan-4-one |
| Platinum, [2-(hydroxy-κO)acetato(2-)-κO]-, ammoniate (1:2) |
| [(Hydroxy-κO)acetato(2-)-κO]platinum diammoniate |
| Nedaplatin |
| o(sup2))-diammine(hydroxyacetato(2-)-o(sup1(sp-4-3)-platinu |
| cis-diammine(glycolato)platinum(ii) |
| PlatinuM,diaMMine[(hydroxy-kO)acetato(2-)-kO]-,(SP-4-3) |
| Nedaplait |
| 254-s |
| cis-diamine-glycolate-O,O'-platinum(II) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does nedaplatin have? |
| A: English synonyms of nedaplatin: (glycolato-O,O')diammine platinum(II), 2,2-diaMino-1,3-dioxa-2-platinacyclopentan-4-one, Platinum, [2-(hydroxy-κO)acetato(2-)-κO]-, ammoniate (1:2), [(Hydroxy-κO)acetato(2-)-κO]platinum diammoniate, Nedaplatin, o(sup2))-diammine(hydroxyacetato(2-)-o(sup1(sp-4-3)-platinu, cis-diammine(glycolato)platinum(ii), PlatinuM,diaMMine[(hydroxy-kO)acetato(2-)-kO]-,(SP-4-3), Nedaplait, 254-s, cis-diamine-glycolate-O,O'-platinum(II). |
| Q: What is the polar surface area (PSA) of nedaplatin? |
| A: Polar surface area (PSA) of nedaplatin is 42.01000. |
| Q: What is the LogP of nedaplatin? |
| A: LogP of nedaplatin is 0.12010. |
| Q: What is the CAS number of nedaplatin? |
| A: CAS number of nedaplatin is 95734-82-0. |
| Q: What is the boiling point of nedaplatin? |
| A: Boiling point of nedaplatin is 265.6ºC at 760 mmHg. |
| Q: What is the molecular formula of nedaplatin? |
| A: Molecular formula of nedaplatin is C2H8N2O3Pt. |
| Q: What is the molecular weight of nedaplatin? |
| A: Molecular weight of nedaplatin is 303.181. |
| Q: What is the InChIKey of nedaplatin? |
| A: InChIKey of nedaplatin is KLNFSAOEKUDMFA-UHFFFAOYSA-M. |
| Q: What are the upstream materials of nedaplatin? |
| A: Related upstream materials(CAS) of nedaplatin: 41575-87-5;25289-18-3;79-14-1;63700-88-9. |
| Q: What is the English name of nedaplatin? |
| A: The English name of nedaplatin is nedaplatin. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Henan Tianfu Chemical Co., Ltd. |