Trimethylapigenin
Modify Date: 2025-08-24 11:44:08
Trimethylapigenin structure
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Common Name | Trimethylapigenin | ||
|---|---|---|---|---|
| CAS Number | 5631-70-9 | Molecular Weight | 312.31700 | |
| Density | 1.242g/cm3 | Boiling Point | 506.5ºC at 760mmHg | |
| Molecular Formula | C18H16O5 | Melting Point | 158-160ºC (dec.) | |
| MSDS | N/A | Flash Point | 225.5ºC | |
Use of Trimethylapigenin5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner[1]. |
| Name | 5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one |
|---|---|
| Synonym | More Synonyms |
| Description | 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner[1]. |
|---|---|
| Related Catalog | |
| Target |
Caspase-3 PARP |
| References |
| Density | 1.242g/cm3 |
|---|---|
| Boiling Point | 506.5ºC at 760mmHg |
| Melting Point | 158-160ºC (dec.) |
| Molecular Formula | C18H16O5 |
| Molecular Weight | 312.31700 |
| Flash Point | 225.5ºC |
| Exact Mass | 312.10000 |
| PSA | 57.90000 |
| LogP | 3.48580 |
| Index of Refraction | 1.585 |
| InChIKey | ZXJJBDHPUHUUHD-UHFFFAOYSA-N |
| SMILES | COc1ccc(-c2cc(=O)c3c(OC)cc(OC)cc3o2)cc1 |
| HS Code | 2932999099 |
|---|
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Name: AUC (0.083 to 4 hrs) in Wistar rat brain at 750 mg/kg, po by LC-MS/MS analysis
Source: ChEMBL
Target: Brain
External Id: CHEMBL3536714
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Name: AUC (0.083 to 4 hrs) in Wistar rat kidney at 750 mg/kg, po by LC-MS/MS analysis
Source: ChEMBL
Target: Kidney
External Id: CHEMBL3536712
|
|
Name: AUC (0.083 to 4 hrs) in Wistar rat lung at 750 mg/kg, po by LC-MS/MS analysis
Source: ChEMBL
Target: Lung
External Id: CHEMBL3536713
|
|
Name: The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre...
Source: 11924
Target: N/A
External Id: CGM data for Cell Systems paper Dec 2015
|
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Name: AUC in Wistar rat at 250 mg/kg, po by HPLC analysis
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL3536698
|
|
Name: AUC in Wistar rat at 250 mg/kg, iv by HPLC analysis
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL3536699
|
|
Name: Elimination rate constant in Wistar rat at 250 mg/kg, po by HPLC analysis
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL3536702
|
|
Name: Elimination rate constant in Wistar rat at 250 mg/kg, iv by HPLC analysis
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL3536703
|
|
Name: Half life in Wistar rat at 250 mg/kg, po by HPLC analysis
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL3536700
|
|
Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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| 4',5,7-Trimethyl-apigenin |
| 4',5,7-Trimethoxyflavone |
| Apigenin trimethyl ether |
| 5,7,4'-Trimethylapigenin |
| apigenin 4',5,7-trimethyl ether |
| Trimethylapigenin |