Trimethylapigenin

Names

[ Name ]:
Trimethylapigenin

[Synonym ]:
4',5,7-Trimethyl-apigenin
4',5,7-Trimethoxyflavone
Apigenin trimethyl ether
5,7,4'-Trimethylapigenin
apigenin 4',5,7-trimethyl ether
Trimethylapigenin

Biological Activity

[Description]:

5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Apoptosis >> Caspase

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

Caspase-3

PARP

[References]

[1]. Kim H, et al. Induction of ER Stress-Mediated Apoptosis by the Major Component 5,7,4'-TrimethoxyflavoneIsolated from Kaempferia parviflora Tea Infusion. Nutr Cancer. 2018 Aug-Sep;70(6):984-996.

Chemical & Physical Properties

[ Density]:
1.242g/cm3

[ Boiling Point ]:
506.5ºC at 760mmHg

[ Melting Point ]:
158-160ºC (dec.)

[ Molecular Formula ]:
C₁₈H₁₆O₅

[ Molecular Weight ]:
312.31700

[ Flash Point ]:
225.5ºC

[ Exact Mass ]:
312.10000

[ PSA ]:
57.90000

[ LogP ]:
3.48580

[ Index of Refraction ]:
1.585

Safety Information

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%