Perindopril erbumine
Perindopril erbumine structure
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Common Name | Perindopril erbumine | ||
|---|---|---|---|---|
| CAS Number | 107133-36-8 | Molecular Weight | 441.605 | |
| Density | 1.15 g/cm3 | Boiling Point | 537.4ºC at 760mmHg | |
| Molecular Formula | C23H43N3O5 | Melting Point | 126-128ºC | |
| MSDS | Chinese USA | Flash Point | 278.8ºC | |
Use of Perindopril erbuminePerindopril erbumine is a potent ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease.Target: ACEPerindopril is a long-acting ACE inhibitor. It is used to treat high blood pressure, heart failure or stable coronary artery disease in form of perindopril arginine (trade names include Coversyl, Coversum) or perindopril erbumine (trade name Aceon). According to the Australian government's Pharmaceutical Benefits Scheme website, based on data provided to the Australian Department of Health and Aging by the manufacturer, perindopril arginine and perindopril erbumine are therapeutically equivalent and may be interchanged without differences in clinical effect. However the dose prescribed to achieve the same effect will differ due to different molecular weights for the two forms. Perindopril is one of the most prescribed inhibitors of angiotensin converting enzyme, has a large evidence base, which allows to use it in patients with hypertension, diabetes mellitus type 2, coronary heart disease and chronic heart failure. In this review, the author focused on the evidence of organoprotecting properties of perindopril that lie outside lowering blood pressure. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | perindopril erbumine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Perindopril erbumine is a potent ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease.Target: ACEPerindopril is a long-acting ACE inhibitor. It is used to treat high blood pressure, heart failure or stable coronary artery disease in form of perindopril arginine (trade names include Coversyl, Coversum) or perindopril erbumine (trade name Aceon). According to the Australian government's Pharmaceutical Benefits Scheme website, based on data provided to the Australian Department of Health and Aging by the manufacturer, perindopril arginine and perindopril erbumine are therapeutically equivalent and may be interchanged without differences in clinical effect. However the dose prescribed to achieve the same effect will differ due to different molecular weights for the two forms. Perindopril is one of the most prescribed inhibitors of angiotensin converting enzyme, has a large evidence base, which allows to use it in patients with hypertension, diabetes mellitus type 2, coronary heart disease and chronic heart failure. In this review, the author focused on the evidence of organoprotecting properties of perindopril that lie outside lowering blood pressure. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.15 g/cm3 |
|---|---|
| Boiling Point | 537.4ºC at 760mmHg |
| Melting Point | 126-128ºC |
| Molecular Formula | C23H43N3O5 |
| Molecular Weight | 441.605 |
| Flash Point | 278.8ºC |
| Exact Mass | 441.320282 |
| PSA | 121.96000 |
| LogP | 3.71330 |
| InChIKey | IYNMDWMQHSMDDE-MHXJNQAMSA-N |
| SMILES | CC(C)(C)N.CCCC(NC(C)C(=O)N1C(C(=O)O)CC2CCCCC21)C(=O)OCC |
| Storage condition | -20°C Freezer |
| Water Solubility | H2O: soluble10mg/mL, clear |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| RTECS | NL5999600 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
|
~95%
Perindopril erbumine CAS#:107133-36-8 |
| Literature: Dubuffet, Thierry; Lecouve, Jean-Pierre Patent: US2007/43103 A1, 2007 ; Location in patent: Page/Page column 2 ; |
|
~62%
Perindopril erbumine CAS#:107133-36-8 |
| Literature: KRKA, tovarna zdravil, d.d., Novo mesto Patent: EP1792896 A1, 2007 ; Location in patent: Page/Page column 7-8 ; |
|
~91%
Perindopril erbumine CAS#:107133-36-8 |
| Literature: QUIMICA SINTETICA, S.A. Patent: WO2006/70276 A1, 2006 ; Location in patent: Page/Page column 8 ; |
|
~%
Perindopril erbumine CAS#:107133-36-8 |
| Literature: WO2006/137082 A1, ; Page/Page column 11-12 ; |
|
~94%
Perindopril erbumine CAS#:107133-36-8 |
| Literature: Dubuffet, Thierry; Lecouve, Jean-Pierre Patent: US2006/178421 A1, 2006 ; Location in patent: Page/Page column 2 ; |
|
~%
Perindopril erbumine CAS#:107133-36-8 |
| Literature: US2006/211867 A1, ; Page/Page column 4 ; |
|
~%
Perindopril erbumine CAS#:107133-36-8 |
| Literature: US2006/211867 A1, ; Page/Page column 3-4 ; |
![N-[(2S)-1-Ethoxy-1-oxo-2-pentanyl]-L-alanine structure](https://image.chemsrc.com/caspic/156/82834-12-6.png)
![N-[1(S)-ethoxycarbonyl-1-butyl]-(S)-alanyl chloride hydrochloride structure](https://image.chemsrc.com/caspic/105/869877-95-2.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 6 | |
|---|---|
| DownStream 3 | |
CAS#:95153-31-4
CAS#:129970-98-5This table lists relevant public references with title, journal and publication metadata for this compound.
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Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.
Clin. Pharmacol. Ther. 96(6) , 713-22, (2014) Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) a... |
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Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs.
Toxicol. Appl. Pharmacol. 274(2) , 328-38, (2014) Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to further characterize the mechanism of early ons... |
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Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.
Drug Metab. Dispos. 42(9) , 1522-31, (2014) Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 pr... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Aceon |
| S 9490-3 |
| PrestariuM |
| (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) (non-preferred name) |
| (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) (non-preferred name) |
| acide (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(éthoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylique - 2-méthylpropan-2-amine (1:1) |
| McN-A 2833-109 |
| McN-A-2833-109 |
| Perinodpril ErbiMune |
| ButylaMiniperindopril |
| Perindoril |
| Perindopril erbumine |
| MFCD02313824 |
| Perindopril tert-butylamine |
| (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxo-2-pentanyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methyl-2-propanamine (1:1) |
| S-9490-3 |
| Perindopril t-Butylamine Salt |
| (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic Acid 1-Ethyl Ester compound with tert-Butylamine (1:1) |
| Procaptan |
| Unii-1964X464oj |
| Coversyl |
| (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(Ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indol-2-carbonsäure--2-methylpropan-2-amin(1:1) |
| (2S-(1(R*(R*)),2a,3ab,7ab))-1-(2-((1-(Ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-1H-indole-2-carboxylic Acid compd. with 2-Methyl-2-propanamine (1:1) |
| Perinodopril |
| Coversum |
| (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) |
| Perindopril t-Butylamine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the downstream products of perindopril erbumine? |
| A: Related downstream products(CAS) of perindopril erbumine: 95153-31-4;129970-98-5;82834-16-0. |
| Q: What is the CAS number of perindopril erbumine? |
| A: CAS number of perindopril erbumine is 107133-36-8. |
| Q: What is the LogP of perindopril erbumine? |
| A: LogP of perindopril erbumine is 3.71330. |
| Q: What are the upstream materials of perindopril erbumine? |
| A: Related upstream materials(CAS) of perindopril erbumine: 82834-16-0;82834-12-6;75-64-9;86647-57-6;869877-95-2;80875-98-5. |
| Q: What is the SMILES notation of perindopril erbumine? |
| A: SMILES notation of perindopril erbumine is CC(C)(C)N.CCCC(NC(C)C(=O)N1C(C(=O)O)CC2CCCCC21)C(=O)OCC. |
| Q: What is the English name of perindopril erbumine? |
| A: The English name of perindopril erbumine is perindopril erbumine. |
| Q: What is the melting point of perindopril erbumine? |
| A: Melting point of perindopril erbumine is 126-128ºC. |
| Q: What is the InChIKey of perindopril erbumine? |
| A: InChIKey of perindopril erbumine is IYNMDWMQHSMDDE-MHXJNQAMSA-N. |
| Q: What is the molecular formula of perindopril erbumine? |
| A: Molecular formula of perindopril erbumine is C23H43N3O5. |
| Q: What is the molecular weight of perindopril erbumine? |
| A: Molecular weight of perindopril erbumine is 441.605. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |