Perindoprilat

Modify Date: 2024-01-02 02:35:22

Perindoprilat structure	Common Name	Perindoprilat
	CAS Number	95153-31-4	Molecular Weight	340.415
	Density	1.2±0.1 g/cm3	Boiling Point	568.1±45.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₂₈N₂O₅	Melting Point	153-155ºC
	MSDS	N/A	Flash Point	297.4±28.7 °C

Use of Perindoprilat

Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research[1][2].

Name	(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
Synonym	More Synonyms

Description	Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
In Vitro	Perindoprilat (1 μM, 10 days) treatment suppresses the angiotensin II production in HNSCC cells[3]. Cell Viability Assay[3] Cell Line: HNSCC cells Concentration: 1 μM Incubation Time: 10 days Result: Suppressed the angiotensin II production in HNSCC cells (P=0.028).
References	[1]. Perindopril. Expert Opin Pharmacother. 2006 Jan;7(1):63-71. [2]. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6.

Density	1.2±0.1 g/cm3
Boiling Point	568.1±45.0 °C at 760 mmHg
Melting Point	153-155ºC
Molecular Formula	C₁₇H₂₈N₂O₅
Molecular Weight	340.415
Flash Point	297.4±28.7 °C
Exact Mass	340.199829
PSA	106.94000
LogP	2.37
Vapour Pressure	0.0±3.4 mmHg at 25°C
Index of Refraction	1.535
Storage condition	-20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL6007250

CHEMICAL NAME :: 1H-Indole-2-carboxylic acid, octahydro-1-(2-((1-carboxybutyl)amino)-1-oxopropyl)-, (2S-(1(R*(R*)),2-alpha,3a-beta,7a-beta))-

CAS REGISTRY NUMBER :: 95153-31-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H28-N2-O5

MOLECULAR WEIGHT :: 340.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 10,446,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 10,446,1992

RIDADR	NONH for all modes of transport

Perindopril erbumine

CAS#:107133-36-8

~72%

Perindoprilat

CAS#:95153-31-4

Literature: Pascard; Guilhem; Vincent; Remond; Portevin; Laubie Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 663 - 669

Perindopril erbumine

CAS#:107133-36-8

~0%

Perindopril Dik...

CAS#:129970-98-5

Perindoprilat

CAS#:95153-31-4

Literature: WO2007/58634 A1, ; Page/Page column 17-19 ;

Precursor 1
CAS#:107133-36-8 Perindopril erbumine
DownStream 0

(2S-(1(R*(R*)),2a,3ab,7ab))-Octahydro-1-(2-((1-carboxybutyl)amino)-1-oxopropyl)-1H-indole-2-carboxylic Acid

(2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic acid

Perindoprilat

(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]-propanoyl]octahydro-1H-indole-2-carboxylic acid

(2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-Carboxybutyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid

S-9780

Perindoprilato [Spanish]

Perindoprilate [French]

UNII-2UV6ZNQ92K

Perindoprilatum [Latin]

DC Chemicals Limited
China
Product Name: Perindoprilat
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

Perindoprilat suppliers

Perindoprilat price

Perindoprilat

Use of Perindoprilat

Names

Perindoprilat Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Synonyms