培哚普利结构式
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常用名 | 培哚普利 | 英文名 | Perindopril erbumine |
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CAS号 | 107133-36-8 | 分子量 | 441.605 | |
密度 | 1.15 g/cm3 | 沸点 | 537.4ºC at 760mmHg | |
分子式 | C23H43N3O5 | 熔点 | 126-128ºC | |
MSDS | 中文版 美版 | 闪点 | 278.8ºC |
培哚普利用途【用途1】 用于治疗高血压、充血性心力衰竭等病症 |
中文名 | 培哚普利叔丁胺盐 |
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英文名 | perindopril erbumine |
中文别名 | 培哚 | 培哚普利 |
英文别名 | 更多 |
描述 | Perindopril是长效血管紧张素转换酶(ACE)抑制剂。 |
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相关类别 | |
参考文献 |
密度 | 1.15 g/cm3 |
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沸点 | 537.4ºC at 760mmHg |
熔点 | 126-128ºC |
分子式 | C23H43N3O5 |
分子量 | 441.605 |
闪点 | 278.8ºC |
精确质量 | 441.320282 |
PSA | 121.96000 |
LogP | 3.71330 |
外观性状 | 白色固体 |
储存条件 | -20°C Freezer |
水溶解性 | H2O: soluble10mg/mL, clear |
~95% 培哚普利 107133-36-8 |
文献:Dubuffet, Thierry; Lecouve, Jean-Pierre Patent: US2007/43103 A1, 2007 ; Location in patent: Page/Page column 2 ; |
~62% 培哚普利 107133-36-8 |
文献:KRKA, tovarna zdravil, d.d., Novo mesto Patent: EP1792896 A1, 2007 ; Location in patent: Page/Page column 7-8 ; |
~91% 培哚普利 107133-36-8 |
文献:QUIMICA SINTETICA, S.A. Patent: WO2006/70276 A1, 2006 ; Location in patent: Page/Page column 8 ; |
~% 培哚普利 107133-36-8 |
文献:WO2006/137082 A1, ; Page/Page column 11-12 ; |
~94% 培哚普利 107133-36-8 |
文献:Dubuffet, Thierry; Lecouve, Jean-Pierre Patent: US2006/178421 A1, 2006 ; Location in patent: Page/Page column 2 ; |
~% 培哚普利 107133-36-8 |
文献:US2006/211867 A1, ; Page/Page column 4 ; |
~% 培哚普利 107133-36-8 |
文献:US2006/211867 A1, ; Page/Page column 3-4 ; |
Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.
Clin. Pharmacol. Ther. 96(6) , 713-22, (2014) Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) a... |
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Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs.
Toxicol. Appl. Pharmacol. 274(2) , 328-38, (2014) Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to further characterize the mechanism of early ons... |
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Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.
Drug Metab. Dispos. 42(9) , 1522-31, (2014) Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 pr... |
Aceon |
S 9490-3 |
PrestariuM |
(2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) (non-preferred name) |
(2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) (non-preferred name) |
acide (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(éthoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylique - 2-méthylpropan-2-amine (1:1) |
McN-A 2833-109 |
McN-A-2833-109 |
Perinodpril ErbiMune |
ButylaMiniperindopril |
Perindoril |
Perindopril erbumine |
MFCD02313824 |
Perindopril tert-butylamine |
(2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxo-2-pentanyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methyl-2-propanamine (1:1) |
S-9490-3 |
Perindopril t-Butylamine Salt |
(2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic Acid 1-Ethyl Ester compound with tert-Butylamine (1:1) |
Procaptan |
Unii-1964X464oj |
Coversyl |
(2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(Ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indol-2-carbonsäure--2-methylpropan-2-amin(1:1) |
(2S-(1(R*(R*)),2a,3ab,7ab))-1-(2-((1-(Ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-1H-indole-2-carboxylic Acid compd. with 2-Methyl-2-propanamine (1:1) |
Perinodopril |
Coversum |
(2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)butyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid - 2-methylpropan-2-amine (1:1) |
Perindopril t-Butylamine |