Perindopril erbumine
Perindopril erbumine structure
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Common Name | Perindopril erbumine | ||
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| CAS Number | 107133-36-8 | Molecular Weight | 441.605 | |
| Density | 1.15 g/cm3 | Boiling Point | 537.4ºC at 760mmHg | |
| Molecular Formula | C23H43N3O5 | Melting Point | 126-128ºC | |
| MSDS | Chinese USA | Flash Point | 278.8ºC | |
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Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.
Clin. Pharmacol. Ther. 96(6) , 713-22, (2014) Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) are also metabolized by this enzyme. We examined the effects... |
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Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs.
Toxicol. Appl. Pharmacol. 274(2) , 328-38, (2014) Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to further characterize the mechanism of early onset of fibrosis in this model and the effects of antifibroti... |
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Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.
Drug Metab. Dispos. 42(9) , 1522-31, (2014) Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 prodrugs. Ten prodrugs in the data set are predominantly hydr... |
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Predicting the effects of blood pressure-lowering treatment on major cardiovascular events for individual patients with type 2 diabetes mellitus: results from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation.
Hypertension 65(1) , 115-21, (2015) Blood pressure-lowering treatment reduces cardiovascular risk in patients with diabetes mellitus, but the effect varies between individuals. We sought to identify which patients benefit most from such treatment in a large clinical trial in type 2 diabetes mel... |
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Comparative study of Mg/Al- and Zn/Al-layered double hydroxide-perindopril erbumine nanocomposites for inhibition of angiotensin-converting enzyme.
Int. J. Nanomedicine 7 , 4251-62, (2012) The intercalation of a drug active, perindopril, into Mg/Al-layered double hydroxide for the formation of a new nanocomposite, PMAE, was accomplished using a simple ion exchange technique. A relatively high loading percentage of perindopril of about 36.5% (w/... |
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[Vascular effects of perindopril arginine and indapamide fixed combination in patients with arterial hypertension].
Kardiologiia 52(9) , 8-14, (2012) The aim of the study was to investigate the dynamics of arterial stiffness and endothelial function parameters under the influence of perindopril arginine and indapamide fixed combination in arterial hypertension (AH) patients. 30 persons with 1-3 degree AH w... |
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Evidence-based triple antihypertensive therapy yields lower mortality in older patients with diabetes mellitus.
Hypertension 63(2) , 220-1, (2014)
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Response to HYVET ambulatory blood pressure substudy.
Hypertension 61(5) , e43, (2013)
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HYVET ambulatory blood pressure substudy.
Hypertension 61(5) , e42, (2013)
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[The FORTISSIMO program: advantages of fixed full dose combination of perindopril arginine and indapamide in the treatment of poorly controlled arterial hypertension].
Kardiologiia 53(3) , 37-43, (2013) In the Russian program FORTISSIMO administration of fixed combination of perindopril arginine/indapamide (10 mg/2.5 mg) in 2120 patients with poorly controlled arterial hypertension instead of angiotensin converting enzyme inhibitors (ACEI) or -receptor antag... |