The Journal of Steroid Biochemistry and Molecular Biology 2013-11-01

Comparative analysis of genes encoding key steroid core oxidation enzymes in fast-growing Mycobacterium spp. strains

E.Yu. Bragin, V.Yu. Shtratnikova, D.V. Dovbnya, M.I. Schelkunov, Yu.A. Pekov, S.G. Malakho, O.V. Egorova, T.V. Ivashina, S.L. Sokolov, V.V. Ashapkin, M.V. Donova

Index: J. Steroid Biochem. Mol. Biol. 138 , 41-53, (2013)

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Abstract

Highlights ► Genomes of three strains of mycobacteria producing 3,17-diketoandrostanes from phytosterol were sequenced. ► Genomes of AD and ADD producers are nearly identical, that of 9-OH-AD producer differs. ► Multiple kstD, kshA and kshB genes were found and annotated. ► AD and ADD-producing strains differ by a Lys135Ser substitution in Δ1 KSTD.