The Journal of Steroid Biochemistry and Molecular Biology 2013-11-01

Comparative analysis of genes encoding key steroid core oxidation enzymes in fast-growing Mycobacterium spp. strains

E.Yu. Bragin, V.Yu. Shtratnikova, D.V. Dovbnya, M.I. Schelkunov, Yu.A. Pekov, S.G. Malakho, O.V. Egorova, T.V. Ivashina, S.L. Sokolov, V.V. Ashapkin, M.V. Donova

文献索引：J. Steroid Biochem. Mol. Biol. 138 , 41-53, (2013)

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摘要

Highlights ► Genomes of three strains of mycobacteria producing 3,17-diketoandrostanes from phytosterol were sequenced. ► Genomes of AD and ADD producers are nearly identical, that of 9-OH-AD producer differs. ► Multiple kstD, kshA and kshB genes were found and annotated. ► AD and ADD-producing strains differ by a Lys135Ser substitution in Δ1 KSTD.