Chemical Communications 2012-02-01

Iron-catalysed, hydride-mediated reductive cross-coupling of vinyl halides and Grignard reagents.

Bryden A F Le Bailly, Mark D Greenhalgh, Stephen P Thomas

Index: Chem. Commun. (Camb.) 48(10) , 1580-2, (2012)

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Abstract

An iron-catalysed, hydride-mediated reductive cross-coupling reaction has been developed for the preparation of alkanes. Using a bench-stable iron(II) pre-catalyst, reductive cross-coupling of vinyl iodides, bromides and chlorides with aryl- and alkyl Grignard reagents successfully gave the products of formal sp(3)-sp(3) cross-coupling reactions.This journal is © The Royal Society of Chemistry 2012