Biochemical Pharmacology 1984-06-01

Effects of various 2-amino-6-alkyldithiopurines on brain specific [3H]diazepam binding.

S C Sung, M Saneyoshi

Index: Biochem. Pharmacol. 33 , 1737-1739, (1984)

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Abstract

Various derivatives of 2-amino-6- methylthiopurine with substituents at the 6-position of purine were tested for their abilities to displace [3H]diazepam binding to rat brain membranes. The potency was dependent on the carbon chain-length in the 6-position of purine. Among the derivatives tested, 2-amino-6-n- pentyldithiopurine had the highest potency, with a Ki value of 0.92 microM.