Organic Letters 2008-04-03

Room-temperature Suzuki-Miyaura couplings in water facilitated by nonionic amphiphiles.

Bruce H Lipshutz, Tue B Petersen, Alexander R Abela

Index: Org. Lett. 10 , 1333, (2008)

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Abstract

Use of a dilute aqueous solution containing a nonionic amphiphile allows efficient Suzuki-Miyaura cross-couplings of arylboronic acids with a wide array of aryl halides and pseudohalides, including sterically hindered and lipophilic substrates, in most cases at room temperature.