Bioorganic & Medicinal Chemistry 2011-05-15

Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents.

Olga N Burchak, Emmanuelle Le Pihive, Laure Maigre, Xavier Guinchard, Pascale Bouhours, Claude Jolivalt, Dominique Schneider, Max Maurin, Carmela Giglione, Thierry Meinnel, Jean-Marc Paris, Jean-Noël Denis

Index: Bioorg. Med. Chem. 19 , 3204, (2011)

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Abstract

A collection of 3-substituted indole derivatives was prepared using nucleophilic addition of indoles to nitrones. The compounds were then tested for their antibacterial activity against almost thirty bacterial strains representative of common human pathogens. Two types of indolic molecules inhibit the growth of Staphylococcus aureus, including MRSA and VISA strains, with MIC values ranging from 8 to 16 mg/L.Copyright © 2011 Elsevier Ltd. All rights reserved.