前往化源商城

Bioorganic & Medicinal Chemistry 2011-05-15

Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents.

Olga N Burchak, Emmanuelle Le Pihive, Laure Maigre, Xavier Guinchard, Pascale Bouhours, Claude Jolivalt, Dominique Schneider, Max Maurin, Carmela Giglione, Thierry Meinnel, Jean-Marc Paris, Jean-Noël Denis

文献索引:Bioorg. Med. Chem. 19 , 3204, (2011)

全文:HTML全文

摘要

A collection of 3-substituted indole derivatives was prepared using nucleophilic addition of indoles to nitrones. The compounds were then tested for their antibacterial activity against almost thirty bacterial strains representative of common human pathogens. Two types of indolic molecules inhibit the growth of Staphylococcus aureus, including MRSA and VISA strains, with MIC values ranging from 8 to 16 mg/L.Copyright © 2011 Elsevier Ltd. All rights reserved.

相关化合物

结构式 名称/CAS号 全部文献
6-氟吲哚 结构式 6-氟吲哚
CAS:399-51-9
环丙沙星 结构式 环丙沙星
CAS:85721-33-1