Synthesis, biological activity, and molecular modeling studies of 1 h-1, 2, 3-triazole derivatives of carbohydrates as α-glucosidases inhibitors

…, CR Kaiser, FP Silva Jr, VF Ferreira

Index: Ferreira, Sabrinab; Sodero, Ana C. R.; Cardoso, Mariana F. C.; Lima, Emerson S.; Kaiser, Carlos R.; Silva Jr., Floriano P.; Ferreira, Vitor F. Journal of Medicinal Chemistry, 2010 , vol. 53, # 6 p. 2364 - 2375

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Citation Number: 120

Abstract

A class of drugs in use for treating type II diabetes mellitus (T2D), typified by the pseudotetrasaccharide acarbose, act by inhibiting the α-glucosidase activity present in pancreatic secretions and in the brush border of the small intestine. Herein, we report the synthesis of a series of 4-substituted 1, 2, 3-triazoles conjugated with sugars, including d- xylose, d-galactose, d-allose, and d-ribose. Compounds were screened for α-glucosidase ...