Different hydrolases involved in bioactivation of prodrug-type angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1

T Ishizuka, Y Yoshigae, N Murayama, T Izumi

Index: Drug Metabolism and Disposition, , vol. 41, # 11 p. 1888 - 1895

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Citation Number: 8

Abstract

... deacetylase as a hydrolase being associated with organ toxicities of clinical drugs such as ... completely converted to their active metabolites through the first pass metabolism before they ... bioactivation of ester compounds hydrolyzed by CMBL in the preclinical drug discovery and ...