Synthetic Communications

Scalable Synthetic Route to 2-Amino-5-hydroxypropiophenone: Efficient Formal Synthesis of Irinotecan

…, R Rao, JS Yadav, M Khagga

Index: Rao, A. V. Rama; Rao, Ramakrishna; Yadav; Khagga, Mukkanti Synthetic Communications, 2013 , vol. 43, # 12 p. 1661 - 1667

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Abstract

2-Amino-5-hydroxypropiophenone, a key precursor in the total synthesis of irinotecan, has been synthesized. Regioselective nitration and a SNAr displacement are the key steps involved in this strategy, which is high yielding, is economical, and has been performed on a plant scale. ... Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.