Abstract A concise and efficient asymmetric process for the total synthesis of (20S)-7-ethyl- 10-hydroxycamptothecin (= SN-38; 1f), an active metabolic form of the prodrug irinotecan, is described. This approach features the enantioselective cyanosilylation of indolizinone 4 into
![(±)- 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy Structure](https://image.chemsrc.com/caspic/342/102978-40-5.png)
