Bioorganic & Medicinal Chemistry 2009-08-01

Interaction of drug based binuclear mixed-ligand complexes with DNA.

Mohan N Patel, Mehulsinh R Chhasatia, Deepen S Gandhi

Index: Bioorg. Med. Chem. 17 , 5648-55, (2009)

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Abstract

Here in we tried to increase an antibacterial activity of ciprofloxacin drug due to formation of mixed-ligand complexes. Synthesized compounds were found to be more potent compare to drugs, ligands and metal salt against selective gram((+ve)) and gram((-ve)) organisms. Interaction of the complexes with nucleic acid (DNA) were investigated using spectroscopic technique, viscosity measurement and gel electrophoresis and it was found that the complexes bind to DNA via intercalative mode.