Bioorganic & Medicinal Chemistry 2015-03-01

Synthesis of (+)-crocacin D and simplified bioactive analogues.

Adele E Pasqua, Frank D Ferrari, James J Crawford, William G Whittingham, Rodolfo Marquez

Index: Bioorg. Med. Chem. 23(5) , 1062-8, (2015)

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Abstract

The total synthesis of (+)-crocacin D has been achieved in 15 steps (9 isolated intermediates) and 14% overall yield from commercially available starting materials and using (+)-crocacin C as a key intermediate. A number of simplified analogues and their biological activities are also reported. Copyright © 2015 Elsevier Ltd. All rights reserved.