Journal of Chromatography B 2013-01-01

LC-MS/MS and GC-MS/MS measurement of plasma and urine di-paracetamol and 3-nitro-paracetamol: Proof-of-concept studies on a novel human model of oxidative stress based on oral paracetamol administration

Arne Trettin, Darko Modun, Sanja Madunic, Jonatan Vukovic, Maja Radman, Sandor Batkai, Thomas Thum, Jens Jordan, Dimitrios Tsikas

Index: J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 959 , 71-81, (2014)

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Abstract

• Proof-of-concept studies in mice and humans by GC-MS/MS and LC-MS/MS. • Paracetamol is metabolized to di-paracetamol and 3-nitro-paracetamol. • di-Paracetamol and 3-nitro-paracetamol occur in plasma and urine. • Molar ratio of di-paracetamol or 3-nitro-paracetamol to paracetamol. • Human model of oxidative stress.