Journal of Chromatography B 2013-01-01

LC-MS/MS and GC-MS/MS measurement of plasma and urine di-paracetamol and 3-nitro-paracetamol: Proof-of-concept studies on a novel human model of oxidative stress based on oral paracetamol administration

Arne Trettin, Darko Modun, Sanja Madunic, Jonatan Vukovic, Maja Radman, Sandor Batkai, Thomas Thum, Jens Jordan, Dimitrios Tsikas

文献索引：J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 959 , 71-81, (2014)

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摘要

• Proof-of-concept studies in mice and humans by GC-MS/MS and LC-MS/MS. • Paracetamol is metabolized to di-paracetamol and 3-nitro-paracetamol. • di-Paracetamol and 3-nitro-paracetamol occur in plasma and urine. • Molar ratio of di-paracetamol or 3-nitro-paracetamol to paracetamol. • Human model of oxidative stress.