Annals of Neurology 2014-04-01

A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta.

Roberta Ricciarelli, Daniela Puzzo, Olga Bruno, Elisa Canepa, Elena Gardella, Daniela Rivera, Lucia Privitera, Cinzia Domenicotti, Barbara Marengo, Umberto Maria Marinari, Agostino Palmeri, Maria Adelaide Pronzato, Ottavio Arancio, Ernesto Fedele

Index: Ann. Neurol. 75(4) , 602-7, (2014)

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Abstract

Cyclic adenosine monophosphate (cAMP) regulates long-term potentiation (LTP) and ameliorates memory in healthy and diseased brain. Increasing evidence shows that, under physiological conditions, low concentrations of amyloid β (Aβ) are necessary for LTP expression and memory formation. Here, we report that cAMP controls amyloid precursor protein (APP) translation and Aβ levels, and that the modulatory effects of cAMP on LTP occur through the stimulation of APP synthesis and Aβ production.© 2014 American Neurological Association.