NKH477
Modify Date: 2024-01-15 22:12:38
NKH477 structure
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Common Name | NKH477 | ||
|---|---|---|---|---|
| CAS Number | 138605-00-2 | Molecular Weight | 546.093 | |
| Density | N/A | Boiling Point | 571.4ºC at 760mmHg | |
| Molecular Formula | C27H44ClNO8 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 176ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of NKH477NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1]. |
| Name | N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylesterβ-alaninehydrochloride |
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| Synonym | More Synonyms |
| Description | NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1]. |
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| Related Catalog | |
| Target |
Adenylate Cyclase[1] |
| In Vivo | NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner[1]. Animal Model: Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g[1] Dosage: 1, 2 or 3 mg/kg/day Administration: Orally; daily; Days 3 and 5 Result: Prolonged lung allograft survival in a dose dependent manner. |
| References |
| Boiling Point | 571.4ºC at 760mmHg |
|---|---|
| Molecular Formula | C27H44ClNO8 |
| Molecular Weight | 546.093 |
| Flash Point | 176ºC |
| Exact Mass | 545.275574 |
| PSA | 122.60000 |
| LogP | 2.82450 |
| Vapour Pressure | 5.29E-16mmHg at 25°C |
| Storage condition | 2-8°C |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 |
| Precautionary Statements | P264-P301 + P310 |
| Hazard Codes | T |
| Safety Phrases | 28-36/37-45 |
| RIDADR | UN 2811 6.1 / PGII |
| RTECS | AY5992600 |
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Analysis of compartmentalized cAMP: a method to compare signals from differently targeted FRET reporters.
Methods Mol. Biol. 1071 , 59-71, (2014) Förster resonance energy transfer (FRET)-based reporters are important tools to study the spatiotemporal compartmentalization of cyclic adenosine monophosphate (cAMP) in living cells. To increase the ... |
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Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach.
J. Mol. Cell Biol. 5(5) , 354-5, (2013) Induced pluripotent stem cells (iPSCs) could be generated by a single gene Oct4 and chemical compounds, in which exogenous expression of Oct4 was indispensable for reprogramming. Recent advances in ch... |
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Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice.
Endocrinology 155(6) , 2122-32, (2014) p21-activated protein kinase-1 (Pak1) plays a role in insulin secretion and glucagon-like peptide-1 (GLP-1) production. Pak1(-/-) mice were found to carry a defect in ip pyruvate tolerance test (IPPTT... |
| (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-Acetoxy-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-6-yl N,N-dimethyl-β-alaninate hydrochloride (1:1) |
| colforsindapropatehydrochloride |
| Adehl |
| β-Alanine, N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester, hydrochloride (1:1) |
| NKH 477 |
| colforsin daropate hydrochloride |
| 6-[3-(dimethylamino)propionyl]-forskolin,Colforsin dapropate hydrochloride,N,N-dimethyl |
| MKH 477 |