Journal of Molecular Cell Biology 2013-10-01

Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach.

Shigeo Masuda, Jun Wu, Tomoaki Hishida, Ganesh N Pandian, Hiroshi Sugiyama, Juan Carlos Izpisua Belmonte

Index: J. Mol. Cell Biol. 5(5) , 354-5, (2013)

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Abstract

Induced pluripotent stem cells (iPSCs) could be generated by a single gene Oct4 and chemical compounds, in which exogenous expression of Oct4 was indispensable for reprogramming. Recent advances in chemical-mediated cellular reprogramming suggest that small molecules alone (i.e. without Yamanaka factors) can successfully establish iPSCs from mouse somatic cells.