Tandem mass spectrometric approaches for the analysis of alkylguanines in human urine

JR Cushnir, S Naylor, JH Lamb…

Index: Cushnir, J. R.; Naylor, S.; Lamb, J. H.; Farmer, P. B. Organic Mass Spectrometry, 1993 , vol. 28, # 5 p. 552 - 558

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Citation Number: 19

Abstract

Abstract Human exposure to carcinogenic alkylating agents can lead to the formation of covalently bound adducts in DNA, some of which are excreted in urine as alkylated purines following DNA degradation and repair. Tandem mass spectrometric methods have been developed for the qualitative and quantitative determination of such alkylpurines in human urine. Short-chain alkyl-and hydroxyalkylguanines have been synthesized with the ...