CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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TZ2975000
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CHEMICAL NAME :
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Propane, 1,2-epoxy-
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CAS REGISTRY NUMBER :
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75-56-9
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BEILSTEIN REFERENCE NO. :
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0079763
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LAST UPDATED :
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199806
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DATA ITEMS CITED :
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122
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MOLECULAR FORMULA :
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C3-H6-O
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MOLECULAR WEIGHT :
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58.09
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WISWESSER LINE NOTATION :
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T3OTJ B1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Open irritation test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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1400 gm/m3/10M
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - headache Gastrointestinal - nausea or vomiting
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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380 mg/kg
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TOXIC EFFECTS :
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Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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4000 ppm/4H
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - dyspnea
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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150 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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440 mg/kg
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TOXIC EFFECTS :
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Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1740 ppm/4H
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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175 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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2005 ppm/4H
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - nausea or vomiting
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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1500 uL/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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660 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Liver - other changes Kidney, Ureter, Bladder - other changes
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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4000 ppm/4H
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - iritis Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - species unspecified
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DOSE/DURATION :
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440 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1170 mg/kg/45D-I
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TOXIC EFFECTS :
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Brain and Coverings - other degenerative changes Liver - other changes Blood - other changes
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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457 ppm/7H/28W-I
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Related to Chronic Data - death
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1433 ppm/6H/12D-I
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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25 mg/m3/4H/26W-I
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TOXIC EFFECTS :
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Brain and Coverings - changes in surface EEG Brain and Coverings - other degenerative changes Vascular - BP lowering not characterized in autonomic section
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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529 ppm/6H/4W-I
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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997 ppm/6H
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TOXIC EFFECTS :
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Cardiac - changes in heart weight Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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125 ppm/6H/13W-I
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TOXIC EFFECTS :
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Related to Chronic Data - death
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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457 ppm/7H/22W-I
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - changes in lung weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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10798 mg/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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400 ppm/6H/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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100 ppm/7H/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Endocrine - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1500 mg/kg/46W-I
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - facilitates action of known carcinogen
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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400 ppm/6H/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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272 mg/kg/95W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease Tumorigenic - tumors at site of application
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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3640 mg/kg/91W-I
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Blood - lymphoma, including Hodgkin's disease Tumorigenic - tumors at site of application
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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868 mg/kg/95W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease Tumorigenic - tumors at site of application
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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2912 mg/kg/95W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease Tumorigenic - tumors at site of application
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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6616 mg/kg/95W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease Tumorigenic - tumors at site of application
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2714 mg/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
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TYPE OF TEST :
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TC - Toxic concentration (other than lowest)
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
-
400 ppm/6H/2Y-I
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TOXIC EFFECTS :
-
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
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TYPE OF TEST :
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TC - Toxic concentration (other than lowest)
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ROUTE OF EXPOSURE :
-
Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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300 ppm/6H/2.3Y-I
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TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors
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TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
-
Inhalation
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DOSE :
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500 ppm/7H
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SEX/DURATION :
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female 7-16 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
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TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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DOSE :
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500 ppm/7H
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SEX/DURATION :
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female 1-16 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
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TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
-
Inhalation
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DOSE :
-
500 ppm/7H
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SEX/DURATION :
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female 15 day(s) pre-mating female 1-16 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - other measures of fertility
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TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
-
Inhalation
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DOSE :
-
100 ppm/7H
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SEX/DURATION :
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male 2 year(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
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TYPE OF TEST :
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Sex chromosome loss and nondisjunction
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TYPE OF TEST :
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Sex chromosome loss and nondisjunction
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TYPE OF TEST :
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Sex chromosome loss and nondisjunction
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TYPE OF TEST :
-
Heritable translocation test
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TYPE OF TEST :
-
Dominant lethal test
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TYPE OF TEST :
-
Micronucleus test
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TYPE OF TEST :
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Cytogenetic analysis
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TYPE OF TEST :
-
Sister chromatid exchange
MUTATION DATA
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TYPE OF TEST :
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DNA adduct
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TEST SYSTEM :
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Mammal - species unspecified Lymphocyte
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REFERENCE :
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CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 67,275,1988 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 48 mg/m3 (20 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,227,1985 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,181,1994 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,227,1985 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,181,1994 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,181,1994 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 100 ppm (240 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,219,1971 OSHA PEL (Gen Indu):8H TWA 100 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 100 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 100 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 100 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 20 ppm (50 mg/m3);Carcinogen JAN 1993 OEL-BELGIUM:TWA 20 ppm (48 mg/m3) JAN 1993 OEL-DENMARK:TWA 5 ppm (12 mg/m3);Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 5 ppm (12 mg/m3);Carcinogen JAN 1993 OEL-FRANCE:TWA 20 ppm (50 mg/m3) JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 100 ppm (240 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 100 ppm (240 mg/m3) JAN 1993 OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 5 ppm (12 mg/m3);STEL 10 ppm (25 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 2.5 ppm (6 mg/m3);Carcinogen JAN 1993 OEL-TURKEY:TWA 100 ppm (240 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 20 ppm (50 mg/m3);STEL 100 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PROPYLENE OXIDE-air:CA lowest feasible concentrtion REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 63550 No. of Facilities: 9032 (estimated) No. of Industries: 78 No. of Occupations: 60 No. of Employees: 75135 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 63550 No. of Facilities: 5786 (estimated) No. of Industries: 57 No. of Occupations: 67 No. of Employees: 421140 (estimated) No. of Female Employees: 317309 (estimated)
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