Tetrahedron Letters

Straightforward access to methyl-polyheterocycles from direct para-lithiation of 3-picoline

J Mathieu, P Gros, Y Fort

Index: Mathieu, Julien; Gros, Philippe; Fort, Yves Tetrahedron Letters, 2001 , vol. 42, # 10 p. 1879 - 1881

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Citation Number: 21

Abstract

Various heterocycles have been introduced on the 3-picoline nucleus via a regioselective BuLi-Me2N (CH2) 2OLi (BuLi-LiDMAE) mediated para-lithiation. Useful methyl- polyheterocycles were efficiently prepared by a one-pot lithiation–stannylation-Stille coupling sequence.

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