Tetrahedron Letters

Palladium (0)-catalysed cross-coupling of 2-trimethylsilylpyridine with aryl halides

DC Blakemore, LA Marples

Index: Blakemore, David C.; Marples, Louise A. Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4192 - 4195

Full Text: HTML

Citation Number: 9

Abstract

Abstract A general method for the Hiyama coupling reaction between aryl halides and 2- trimethylsilylpyridine has been developed. These conditions have been successfully applied to the synthesis of bis-heteroaryl systems, a key disconnection for the pharmaceutical industry in the synthesis of drug-like molecules.

 Related Synthetic Route

~56%

Learn More

~61%

Learn More

~82%

Learn More

~62%

Learn More

~68%

Learn More

~10%

Learn More

~%

Learn More

~92%

Learn More

~79%

Learn More

~38%

Learn More

~99%

Learn More

~71%

Learn More

~58%

Learn More

~70%

Learn More

~90%

Learn More