Tetrahedron Letters

Palladium (0)-catalysed cross-coupling of 2-trimethylsilylpyridine with aryl halides

DC Blakemore, LA Marples

Index: Blakemore, David C.; Marples, Louise A. Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4192 - 4195

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Citation Number: 9

Abstract

Abstract A general method for the Hiyama coupling reaction between aryl halides and 2- trimethylsilylpyridine has been developed. These conditions have been successfully applied to the synthesis of bis-heteroaryl systems, a key disconnection for the pharmaceutical industry in the synthesis of drug-like molecules.

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~10%

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~38%

~99%

~71%

~58%

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~90%

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