Tetrahedron

Kinetic resolution of primary amines via enantioselective N-acylation with acyl chlorides in the presence of supramolecular cyclodextrin nanocapsules

H Asahara, T Kida, T Iwamoto, T Hinoue, M Akashi

Index: Asahara, Haruyasu; Kida, Toshiyuki; Iwamoto, Takuya; Hinoue, Tomoaki; Akashi, Mitsuru Tetrahedron, 2014 , vol. 70, # 2 p. 197 - 203

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Citation Number: 2

Abstract

Abstract The non-enzymatic kinetic resolution of primary amines via enantioselective N- acylation with acyl chlorides was accomplished for the first time by using the selective sequestration of one enantiomer within a supramolecular cyclodextrin (CD) nanocapsule in nonpolar solvents. In addition, the first example of a crystalline structure for an inclusion complex between an acyl chloride and a CD derivative is reported.