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e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

α-Hydroxy Amides and Related Compounds

SL Shapiro, IM Rose, L Freedman

Index: Shapiro et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 6322,6323

Full Text: HTML

Citation Number: 33

Abstract

While a wide variety of recent studies of carboxylic acid amides hasshown pharmacological activity, there has been relatively little systematic explorntion2 of the amides of a-hydroxy acids. Studies3 of such amides, and derivatives of these conipounds of the type I are herein described.

 Related Synthetic Route
Ethyl 2-hydroxyacetate Structure

623-50-7

Ethyl 2-hydroxy...

 Structure

74497-02-2

~%

GLYCOLANILIDE Structure

4746-61-6

GLYCOLANILIDE

2-Piperazinoethylamine Structure

140-31-8

2-Piperazinoeth...

Ethyl 2-hydroxyacetate Structure

623-50-7

Ethyl 2-hydroxy...

~%

2-hydroxy-N-(2-piperazin-1-ylethyl)acetamide Structure

98487-69-5

2-hydroxy-N-(2-...

p-Toluidine Structure

106-49-0

p-Toluidine

Ethyl α-hydroxyisobutyrate Structure

80-55-7

Ethyl α-hydroxy...

~%

2-hydroxy-2-methyl-N-(4-methylphenyl)propanamide Structure

7595-58-6

2-hydroxy-2-met...

2,6-xylidine Structure

87-62-7

2,6-xylidine

~%

lactoxylidide Structure

29183-17-3

lactoxylidide

methylpiperazine Structure

109-01-3

methylpiperazine

Ethyl 2-hydroxyacetate Structure

623-50-7

Ethyl 2-hydroxy...

~%

Piperazine, 1-(hydroxyacetyl)-4-methyl- (9CI) Structure

91406-27-8

Piperazine, 1-(...

4-Chloroaniline Structure

106-47-8

4-Chloroaniline

Ethyl α-hydroxyisobutyrate Structure

80-55-7

Ethyl α-hydroxy...

~%

N-(4-Chlorophenyl)-2-hydroxy-2-methylpropanamide Structure

62100-41-8

N-(4-Chlorophen...

Ethyl lactate Structure

97-64-3

Ethyl lactate

Isobutylamine Structure

78-81-9

Isobutylamine

~%

Propanamide,2-hydroxy-N-(2-methylpropyl)- Structure

5422-36-6

Propanamide,2-h...

methylpiperazine Structure

109-01-3

methylpiperazine

Ethyl lactate Structure

97-64-3

Ethyl lactate

~%

2-hydroxy-1-(4-methylpiperazin-1-yl)propan-1-one Structure

98998-54-0

2-hydroxy-1-(4-...

o-Toluidine Structure

95-53-4

o-Toluidine

Ethyl α-hydroxyisobutyrate Structure

80-55-7

Ethyl α-hydroxy...

~%

2-hydroxy-2-methyl-N-(2-methylphenyl)propanamide Structure

62100-42-9

2-hydroxy-2-met...

p-Anisidine Structure

104-94-9

p-Anisidine

Ethyl α-hydroxyisobutyrate Structure

80-55-7

Ethyl α-hydroxy...

~%

2-hydroxy-N-(4-methoxyphenyl)-2-methylpropanamide Structure

62100-43-0

2-hydroxy-N-(4-...

 Structure

74497-02-2

Ethyl α-hydroxyisobutyrate Structure

80-55-7

Ethyl α-hydroxy...

~%

2-hydroxy-2-methyl-N-phenylpropanamide Structure

2760-38-5

2-hydroxy-2-met...

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Detail Synthetic Route


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