2-Piperazinoethylamine

Modify Date: 2024-01-01 19:29:02

2-Piperazinoethylamine Structure
2-Piperazinoethylamine structure
Common Name 2-Piperazinoethylamine
CAS Number 140-31-8 Molecular Weight 129.203
Density 1.0±0.1 g/cm3 Boiling Point 220.0±8.0 °C at 760 mmHg
Molecular Formula C6H15N3 Melting Point -19 °C
MSDS Chinese USA Flash Point 93.3±0.0 °C
Symbol GHS05 GHS06
GHS05, GHS06
Signal Word Danger

 Names

Name N-Aminoethylpiperazine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 220.0±8.0 °C at 760 mmHg
Melting Point -19 °C
Molecular Formula C6H15N3
Molecular Weight 129.203
Flash Point 93.3±0.0 °C
Exact Mass 129.126602
PSA 41.29000
LogP -0.86
Vapour density 4.4 (vs air)
Vapour Pressure 0.1±0.4 mmHg at 25°C
Index of Refraction 1.479
Stability Stable. Flammable. Incompatible with acids, acid anhydrides, acid chlorides, strong oxidizing agents, chloroformates.
Water Solubility soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TK8050000
CHEMICAL NAME :
Piperazine, 1-(2-aminoethyl)-
CAS REGISTRY NUMBER :
140-31-8
BEILSTEIN REFERENCE NO. :
0104363
LAST UPDATED :
199710
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C6-H15-N3
MOLECULAR WEIGHT :
129.24
WISWESSER LINE NOTATION :
T6M DNTJ D2Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2140 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
880 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1680 mg/kg
SEX/DURATION :
male 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
500 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 320,31,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1937 No. of Facilities: 328 (estimated) No. of Industries: 11 No. of Occupations: 17 No. of Employees: 11542 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1937 No. of Facilities: 4514 (estimated) No. of Industries: 42 No. of Occupations: 41 No. of Employees: 60625 (estimated) No. of Female Employees: 12978 (estimated)

 Safety Information

Symbol GHS05 GHS06
GHS05, GHS06
Signal Word Danger
Hazard Statements H302-H311-H314-H317-H412
Precautionary Statements P273-P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C:Corrosive;
Risk Phrases R21/22;R34;R43;R52/53
Safety Phrases S26-S36/37/39-S45-S61
RIDADR UN 2815 8/PG 3
WGK Germany 2
RTECS TK8050000
Packaging Group III
Hazard Class 8
HS Code 2933599090

 Synthetic Route

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles20

More Articles
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.

Bioorg. Med. Chem. 16 , 3530-6, (2008)

The first activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms associated to tumors, hCA IX and XII, with a small library of natural and non-natural amino acids as well as aroma...

Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.

Bioorg. Med. Chem. Lett. 16 , 3955-9, (2006)

The first activation study of isoform XIII of carbonic anhydrase (CA, EC 4.2.1.1) is reported. A series of amino acids and amines incorporating protonatable moieties of the primary/heterocyclic amine ...

Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.

Bioorg. Med. Chem. 15 , 5351-7, (2007)

The secretory isozyme of human carbonic anhydrase (hCA, EC 4.2.1.1), hCA VI, has been cloned, expressed, and purified in a bacterial expression system. The kinetic parameters for the CO(2) hydration r...

 Synonyms

2-piperazin-1-ylethanamine
2-Piperazinoethylamine
1-(2-Aminoethyl)piperazine
N-(2-Aminoethyl)piperazin
N-(2-Aminoethyl)piperazine
2-(1-Piperazinyl)ethanamine
Piperazine, 1- (2-aminoethyl)-
N-(β-Aminoethyl)piperazine
1-(2-aminoethyl) piperazine
2-(piperazin-1-yl)ethanamine
EINECS 205-411-0
1-Piperazineethanamine
MFCD00005971
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