Journal of the American Chemical Society

Palladium-catalyzed coupling of ammonia with aryl chlorides, bromides, iodides, and sulfonates: A general method for the preparation of primary arylamines

GD Vo, JF Hartwig

Index: Vo, Giang D.; Hartwig, John F. Journal of the American Chemical Society, 2009 , vol. 131, # 31 p. 11049 - 11061

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Citation Number: 179

Abstract

We report that the complex generated from Pd [P (o-tol) 3] 2 and the alkylbisphosphine CyPF- t-Bu is a highly active and selective catalyst for the coupling of ammonia with aryl chlorides, bromides, iodides, and sulfonates. The couplings of ammonia with this catalyst conducted with a solution of ammonia in dioxane form primary arylamines from a variety of aryl electrophiles in high yields. Catalyst loadings as low as 0.1 mol% were sufficient for ...