Caerulein ammonium salt
Caerulein ammonium salt structure
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Common Name | Caerulein ammonium salt | ||
|---|---|---|---|---|
| CAS Number | 17650-98-5 | Molecular Weight | 980.051 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C58H73N13O21S2 | Melting Point | 224-226° (dec) | |
| MSDS | Chinese USA | Flash Point | N/A | |
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p21(WAF1) (/Cip1) limits senescence and acinar-to-ductal metaplasia formation during pancreatitis.
J. Pathol. 235(3) , 502-14, (2015) Trans-differentiation of pancreatic acinar cells into ductal-like lesions, a process defined as acinar-to-ductal metaplasia (ADM), is observed in the course of organ regeneration following pancreatitis. In addition, ADM is found in association with pre-malign... |
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Overexpression of Fas and FasL is associated with infectious complications and severity of experimental severe acute pancreatitis by promoting apoptosis of lymphocytes.
Inflammation 37(4) , 1202-12, (2014) This study investigated the relationship of Fas and Fas ligand (FasL) expression and apoptosis of lymphocytes in relation to the pathogenic immune response and infectious complications observed in experimental severe acute pancreatitis in mice. Forty male Bal... |
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A novel 2-step culture model for long-term in vitro maintenance of human pancreatic acinar cells.
Pancreas 43(5) , 762-7, (2014) Because of rapid loss of functional differentiation that regularly occurs in vitro, culture systems permitting long-term studies on pancreatic acinar cells pose a major technical challenge. We recently described a method for long-term cultivation of mouse aci... |
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Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity.
Gastroenterology 146(7) , 1763-74, (2014) The NACHT, LRR, and pyrin domain-containing protein 3 (NLRP3) inflammasome induces inflammation in response to organ injury, but little is known about its regulation. Toll-like receptors (TLRs) provide the first signal required for activation of the inflammas... |
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Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes.
Gut 62(9) , 1328-39, (2013) Fibrosis associated with chronic pancreatitis is an irreversible lesion that can disrupt pancreatic exocrine and endocrine function. Currently, there are no approved treatments for this disease. We previously showed that siRNA against collagen-specific chaper... |
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Shikonin ameliorates cerulein-induced acute pancreatitis in mice.
J. Ethnopharmacol. 145(2) , 573-80, (2013) Shikonin, a highly liposoluble naphthoquinone pigment isolated from the traditional medical herbs Lithospermum erythrorhizon (LE), was considered to exhibit an anti-inflammatory property. While the potential of shikonin to ameliorate acute pancreatitis (AP) i... |
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Regulation of pancreatic inflammation by connective tissue growth factor (CTGF/CCN2).
Immunology 141(4) , 564-76, (2014) Pancreatitis is caused by long-term heavy alcohol consumption, which results in injury and death of pancreatic acinar cells (PAC). The PAC play a pivotal role in mediating early inflammatory responses but the underlying mechanisms remain poorly understood. Tr... |
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Roles of prefrontal cortex and paraventricular thalamus in affective and mechanical components of visceral nociception.
Pain 156 , 2479-91, (2015) Visceral pain represents a major clinical challenge in the management of many gastrointestinal disorders, eg, pancreatitis. However, cerebral neurobiological mechanisms underlying visceral nociception are poorly understood. As a representative model of viscer... |
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The effect of sulindac, a non-steroidal anti-inflammatory drug, attenuates inflammation and fibrosis in a mouse model of chronic pancreatitis.
BMC Gastroenterol. 12 , 115, (2012) Chronic pancreatitis is characterized by progressive fibrosis, pain and loss of exocrine and endocrine functions. The long-standing chronic pancreatitis and its associated pancreatic fibrosis are the most common pathogenic events involved in human pancreatic ... |
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Diosmetin ameliorates the severity of cerulein-induced acute pancreatitis in mice by inhibiting the activation of the nuclear factor-κB.
Int. J. Clin. Exp. Pathol. 7(5) , 2133-42, (2014) Diosmetin (3', 5, 7-trihydroxy-4'-methoxyflavone), the aglycone part of the flavonoid glycosides diosmin occurs naturally in citrus fruit, was considered to exhibit anti-inflammatory and antioxidant properties. Our study aimed to investigate the effect of dio... |