(R,S)-AMPA(mM/ml)

(R,S)-AMPA(mM/ml) Structure
(R,S)-AMPA(mM/ml) structure
Common Name (R,S)-AMPA(mM/ml)
CAS Number 74341-63-2 Molecular Weight 186.165
Density 1.5±0.1 g/cm3 Boiling Point 425.6±45.0 °C at 760 mmHg
Molecular Formula C7H10N2O4 Melting Point 240-252ºC
MSDS USA Flash Point 211.2±28.7 °C

Differential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenula.

J. Neurosci. 34(29) , 9789-802, (2014)

Neuronal nAChRs in the medial habenula (MHb) to the interpeduncular nucleus (IPN) pathway are key mediators of nicotine's aversive properties. In this paper, we report new details regarding nAChR anatomical localization and function in MHb and IPN. A new grou...

TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs.

Nat. Neurosci. 16(9) , 1266-74, (2013)

Regulation of calcium-permeable AMPA receptors (CP-AMPARs) is crucial in normal synaptic function and neurological disease states. Although transmembrane AMPAR regulatory proteins (TARPs) such as stargazin (γ-2) modulate the properties of calcium-impermeable ...

Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage.

Ann. Neurol. 75(4) , 492-507, (2014)

Hypoglycemia is a common adverse event and can injure central nervous system (CNS) white matter (WM). We determined whether glutamate receptors were involved in hypoglycemic WM injury.Mouse optic nerves (MON), CNS WM tracts, were maintained at 37°C with oxyge...

Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior.

J. Neurosci. 32(43) , 15124-32, (2012)

We found previously that acute ex vivo as well as repeated cycles of in vivo ethanol exposure and withdrawal, including excessive voluntary consumption of ethanol, produces a long-lasting increase in the activity of NR2B-containing NMDA receptors (NR2B-NMDARs...

A subtype-specific function for the extracellular domain of neuroligin 1 in hippocampal LTP.

Neuron 76(2) , 309-16, (2012)

At neuronal excitatory synapses, two major subtypes of the synaptic adhesion molecule neuroligin are present. These subtypes, neuroligin 1 and neuroligin 3, have roles in synaptogenesis and synaptic maintenance that appear largely overlapping. In this study, ...

In vivo recordings of GnRH neuron firing reveal heterogeneity and dependence upon GABAA receptor signaling.

J. Neurosci. 33(22) , 9394-401, (2013)

The gonadotropin-releasing hormone (GnRH) neurons are the key cells regulating fertility in all mammalian species. The scattered distribution of these neurons has made investigation of their properties extremely difficult and the key goal of recording their e...

NGL-2 Regulates Input-Specific Synapse Development in CA1 Pyramidal Neurons

Neuron 76(4) , 762-75, (2012)

An important organizing feature of the CNS is that individual neurons receive input from many different sources. Independent regulation of synaptic input is critical for the function and adaptive responses of the nervous system, but the underlying molecular m...

NMDAR-regulated dynamics of layer 4 neuronal dendrites during thalamocortical reorganization in neonates.

Neuron 82(2) , 365-79, (2014)

Thalamocortical (TC) connectivity is reorganized by thalamic inputs during postnatal development; however, the dynamic characteristics of TC reorganization and the underlying mechanisms remain unexplored. We addressed this question using dendritic refinement ...

Synaptic potentiation in the nociceptive amygdala following fear learning in mice.

Mol. Brain 6 , 11, (2013)

Pavlovian fear conditioning is a classical form of associative learning, which depends on associative synaptic plasticity in the amygdala. Recent findings suggest that the central amygdala (CeA) plays an active role in the acquisition of fear learning. Howeve...

Cornichons control ER export of AMPA receptors to regulate synaptic excitability.

Neuron 80(1) , 129-42, (2013)

The strength of synaptic communication at central synapses depends on the number of ionotropic glutamate receptors, particularly the class gated by the agonist AMPA (AMPARs). Cornichon proteins, evolutionarily conserved endoplasmic reticulum cargo adaptors, m...