CAINDEXNAME:GUANIDINE,[(3-IODOPHENYL)METHYL]
![CAINDEXNAME:GUANIDINE,[(3-IODOPHENYL)METHYL] Structure](https://image.chemsrc.com/caspic/215/80663-95-2.png)
CAINDEXNAME:GUANIDINE,[(3-IODOPHENYL)METHYL] structure
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Common Name | CAINDEXNAME:GUANIDINE,[(3-IODOPHENYL)METHYL] | ||
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| CAS Number | 80663-95-2 | Molecular Weight | 648.25800 | |
| Density | 1.85g/cm3 | Boiling Point | 382.1ºC at 760mmHg | |
| Molecular Formula | C16H22I2N6O4S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 184.9ºC | |
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Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65.
Sci. Signal. 7(351) , ra106, (2014) Inflammation increases the abundance of inducible nitric oxide synthase (iNOS), leading to enhanced production of nitric oxide (NO), which can modify proteins by S-nitrosylation. Enhanced NO production increases the activities of the transcription factors p53... |
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The effects of MIBG on the invasive properties of HepG2 hepatocellular carcinoma cells.
Int. J. Mol. Med. 34(3) , 842-8, (2014) The aim of the present study was to investigate the effects of meta-iodobenzylguanidine (MIBG) on the invasive properties of hepatocellular carcinoma (HCC) cells and examine whether these effects are due to the ability of MIBG to inhibit arginine-specific mon... |
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Patient-specific dosimetry using pretherapy [¹²⁴I]m-iodobenzylguanidine ([¹²⁴I]mIBG) dynamic PET/CT imaging before [¹³¹I]mIBG targeted radionuclide therapy for neuroblastoma.
Mol. Imaging Biol. 17(2) , 284-94, (2015) Iodine-131-m-iodobenzylguanidine ([(131)I]mIBG)-targeted radionuclide therapy (TRT) is a standard treatment for recurrent or refractory neuroblastoma with response rates of 30-40 %. The aim of this study is to demonstrate patient-specific dosimetry using quan... |
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A Comparison of Quantitative T2 Mapping on Cardiovascular Magnetic Resonance Imaging with Metaiodobenzylguanidine Scintigraphy and Left Ventricular Functional Recovery in Dilated Cardiomyopathy: A Retrospective Pilot Study.
Intern. Med. 54 , 2121-8, (2015) Metaiodobenzylguanidine (MIBG) scintigraphy is used to assess heart failure (HF) severity and to predict cardiac functional recovery. Cardiovascular magnetic resonance (CMR) imaging has recently been used to diagnosis HF. We evaluated CMR T2 mapping and MIBG ... |
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Meta-iodobenzylguanidine (MIBG), a novel high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation).
Biochim. Biophys. Acta 1037 , 92, (1990) Meta-iodobenzylguanidine (MIBG) is a guanidine analogue of the neurotransmitter norepinephrine. Radioiodinated [131I]MIBG is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. Moreover, non-radiolabell... |
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Cytotoxic and antitumor effects of the norepinephrine analogue meta-iodo-benzylguanidine (MIBG).
Cancer Chemother. Pharmacol. 21 , 9, (1988) Meta-iodo-benzylguanidine (MIBG) is an analogue of the neurotransmitter norepinephrine. In its radioiodinated form, MIBG is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. The potential cytotoxicity... |
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Diagnostic value of MIBG cardiac scintigraphy for differential dementia diagnosis.
Int. J. Geriatr. Psychiatry 30 , 864-9, (2015) Iodine-123 metaiodobenzylguanidine (MIBG) cardiac scintigraphy has shown the potential to discriminate dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). However, these studies did not reflect clinical practice, as patients with ischemic heart dis... |
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Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma.
Clin. Cancer Res. 21 , 2715-21, (2015) (131)I-metaiodobenzylguanidine (MIBG) is a radiopharmaceutical with activity in neuroblastoma. Vorinostat is a histone deacetylase inhibitor that has radiosensitizing properties. The goal of this phase I study was to determine the MTDs of vorinostat and MIBG ... |
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Potential diagnostic value of regional myocardial adrenergic imaging using (123)I-MIBG SPECT to identify patients with Lewy body diseases.
Eur. J. Nucl. Med. Mol. Imaging 42 , 1043-51, (2015) The aim of this study was to determine the potential diagnostic value of regional myocardial adrenergic (123)I-metaiodobenzylguanidine (MIBG) single photon emission computed tomography (SPECT) imaging to identify patients with Lewy body diseases (LBD+).Sixty-... |
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Longitudinal Evaluation of Sympathetic Nervous System and Perfusion in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic Single-Photon Emission Computed Tomography.
Mol. Imaging 14 , 373-84, (2015) The objective of this work was to evaluate the sympathetic nervous system and structure remodeling during the progression of heart failure in a rodent model using dynamic cardiac single-photon emission computed tomography (SPECT). The spontaneously hypertensi... |