S3I-201
S3I-201 structure
|
Common Name | S3I-201 | ||
|---|---|---|---|---|
| CAS Number | 501919-59-1 | Molecular Weight | 365.358 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 654.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C16H15NO7S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 349.8±31.5 °C | |
|
STAT3 regulates steady-state expression of synaptopodin in cultured mouse podocytes.
Mol. Pharmacol. 87(2) , 231-9, (2014) The transcription factor signal transducer and activator of transcription-3 (STAT3) is activated by proinflammatory cytokines and circulating factors in many cell types. Synaptopodin (Synpo) is a cytoskeleton regulatory protein expressed in podocyte foot proc... |
|
|
Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses.
Vet. Res. 45 , 118, (2014) Highly pathogenic avian influenza (HPAI) H5N1 viruses cause severe infection in chickens at near complete mortality, but corresponding infection in ducks is typically mild or asymptomatic. To understand the underlying molecular differences in host response, p... |
|
|
Enhanced miR-210 expression promotes the pathogenesis of endometriosis through activation of signal transducer and activator of transcription 3.
Hum. Reprod. 30(3) , 632-41, (2015) What are the roles of the microRNA miR-210-an miRNA that is up-regulated in endometriotic cyst stromal cells (ECSCs)-in the pathogenesis of endometriosis?Up-regulated miR-210 expression in ECSCs is involved in their proliferation, resistance to apoptosis and ... |
|
|
Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN.
Blood 125 , 2131-40, (2015) The acquired somatic JAK2-V617F mutation is present in >80% of patients with myeloproliferative neoplasms (MPNs). Stat3 plays a role in hematopoietic homeostasis and might influence the JAK2-V617F-driven MPN phenotype. We crossed our transgenic SclCre;V617F m... |
|
|
Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells.
Oncotarget 6 , 38239-56, (2015) Epithelial to mesenchymal transition (EMT) induces cell plasticity and promotes metastasis. The multifunctional oncoprotein Y-box binding protein-1 (YB-1) and the pleiotropic cytokine interleukin 6 (IL-6) have both been implicated in tumor cell metastasis and... |
|
|
The Nogo/Nogo Receptor (NgR) Signal Is Involved in Neuroinflammation through the Regulation of Microglial Inflammatory Activation.
J. Biol. Chem. 290 , 28901-14, (2015) Microglia have been proposed to play a pivotal role in the inflammation response of the CNS by expressing a range of proinflammatory enzymes and cytokines under pathological stimulus. Our previous study has confirmed that Nogo receptor (NgR), an axon outgrowt... |
|
|
Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.
Cell Cycle 14 , 1842-58, (2015) Polyploid decidual cells are specifically differentiated cells during mouse uterine decidualization. However, little is known about the regulatory mechanism and physiological significance of polyploidization in pregnancy. Here we report a novel role of E2F8 i... |
|
|
Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression.
Clin. Cancer Res. 21(1) , 201-10, (2015) To unravel the role of interleukin (IL)-6 and insulin-like growth factor (IGF)-I receptor (IGFIR) in expressing stemness-related properties and to evaluate the prognostic values of pluripotent transcription factor OCT4/NANOG, and IGFIR in hepatocellular carci... |
|
|
p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways.
Oncotarget 6 , 16963-80, (2015) The p53 tumor suppressor regulates transcription of genes associated with diverse cellular functions including apoptosis, growth arrest, DNA repair and differentiation. Recently, we established that p53 can modulate expression of Toll-like receptor (TLR) inna... |
|
|
Novel quinazoline derivatives exhibit antitumor activity by inhibiting JAK2/STAT3.
Oncol. Rep. 34 , 1875-82, (2015) Quinazoline core-containing compounds such as gefitinib and erlotinib constitute an important group of antitumor drugs that act as receptor tyrosine kinase inhibitors against epidermal growth factor receptor (EGFR) kinase activity. We investigated a group of ... |